17959-64-7Relevant articles and documents
Double - (to - alkoxybenzyl propenone) glutathione - S - transfers the sulfur of the enzyme dives inhibitors
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Paragraph 0080-0083, (2020/05/08)
The invention discloses a bis-(p-alkoxy benzene acrylketone) like glutathione-S-transferase potential inhibitor. Structure and living features of the potential inhibitor are as follows: two p-alkoxy benzene acrylketone units are linked to two amino groups, alcoholic hydroxyl groups and carboxyl groups or one amino group and one alcoholic hydroxyl group which are spaced by less than 8 single bonds through amide and/or ester bond, wherein compounds obtained are substrate and inhibitor of glutathione-S-transferase, namely GST; the GST catalyzes carbon-carbon bond and reduced glutathione, namely GSH, of alpha, beta-unsaturated ketone of each p-alkoxy benzene acrylketone unit in the compounds and generates a compound, namely product, through Michael addition. The product shows a stronger inhibiting efficacy on the GST, so that the compound is a GST potential inhibitor; the product has a stronger inhibiting efficacy on human GST isozyme mu in comparison with human GST isozyme alpha and pi; and the compounds can enter into cells, and can enhance inhibiting effect of cis-platinum on drug-resistant carcinoma cell growth.
THIAZOLE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS
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Page/Page column 35, (2010/04/03)
The present invention provides thiazole derivatives as Stearoyl CoA Desaturase (SCD) inhibitors. In particular, the compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase