1799711-21-9

Basic information

• Product Name: dBET1
• Synonyms: dBET1
• CAS NO: 1799711-21-9
• Molecular Formula: C38H37ClN8O7S
• Molecular Weight: 785.26778
• EINECS: -0
• Mol File: 1799711-21-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.68±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: dBET1(CAS DataBase Reference)
• NIST Chemistry Reference: dBET1(1799711-21-9)
• EPA Substance Registry System: dBET1(1799711-21-9)

Safety Data

• Hazardous Substances Data: 1799711-21-9(Hazardous Substances Data)

Usage

Description

dBET1 is a PROTAC compound that consists of a BET bromodomain antagonist (+)-JQ1 linked to a cereblon E3 ubiquitin ligase ligand. It is designed to induce the degradation of BET proteins, which play a crucial role in the regulation of gene expression and are often dysregulated in various cancers.

Uses

Used in Oncology:
dBET1 is used as a targeted therapy for the treatment of cancers with dysregulated BET proteins. It induces highly selective cereblon-dependent BET protein degradation in vitro and in vivo, leading to the suppression of cancer cell growth and proliferation.
Used in Leukemia Research:
dBET1 is used as a potential therapeutic agent for delaying leukemia progression in mice. Its ability to degrade BET proteins may offer a promising approach for the treatment of leukemia and other hematological malignancies.