1801-18-9

Basic information

• Product Name: 3-amino-N-phenylbut-2-enamide
• CAS NO: 1801-18-9
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.2151
• Mol File: 1801-18-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 361.2°C at 760 mmHg
• Flash Point: 172.3°C
• Density: 1.154g/cm³
• Vapor Pressure: 2.1E-05mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 3-amino-N-phenylbut-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-N-phenylbut-2-enamide(1801-18-9)
• EPA Substance Registry System: 3-amino-N-phenylbut-2-enamide(1801-18-9)

Safety Data

• Hazardous Substances Data: 1801-18-9(Hazardous Substances Data)

Upstream product

• 102-01-2 N-phenylacetoacetamide 
• 7664-41-7 ammonia 
• 626-34-6 ethyl aminocrotonate 
• 62-53-3 aniline 

Downstream Products

• 111961-65-0 3-amino-butyric acid anilide 
• 32363-53-4 2,6-dimethyl-3-phenyl-4(3H)-pyrimidinone 
• 78944-54-4 (3,6-Dimethyl-1,5-dioxo-4-aza-2-heptenylamino)benzene 
• 53399-22-7 5-bromo-6-methyl-3-phenyl-3H-pyrimidin-4-one 
• 78944-58-8 (3,7-Dimethyl-1,5-dioxo-4-aza-2-octenylamino)benzene 
• 105707-05-9 5-Benzoylamino-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide 
• 143755-71-9 2,6-Dimethyl-4-phenyl-5-phenylcarbamoyl-nicotinic acid ethyl ester 
• 143755-87-7 4-phenyl-5-ethoxycarbonyl-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid N-phenyl-N-methylamide 
• 143755-92-4 4-phenyl-5-ethoxycarbonyl-1,2,6-trimethyl-1,4-dihydropyridine-3-carboxylic acid N-phenyl-N-methylamide 
• 56537-59-8 (E)-3-amino-N-phenyl-2-(phenylthio)but-2-enamide 
• 1421852-10-9 2,5-dimethyl-3-oxo-N²,N⁴-diphenyl-2,3-dihydro-1H-pyrrole-2,4-dicarboxamide 
• 1374229-41-0 2,5-dimethyl-N,4-diphenyl-1H-pyrrole-3-carboxamide 
• 869792-42-7 3-[N-(tert-butoxycarbonyl)amino]-N-phenylbutanamide 

Relevant articles and documents

Lewis Acid-Mediated [3+3] Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives

A direct and single-step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid-promoted [3+3] annulation between 3-ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope. (Figure presented.).

Detection and elimination of product inhibition from the asymmetric catalytic hydrogenation of enamines

(Chemical Equation Presented) The catalytic asymmetric hydrogenation of enamine amides and esters with catalyst Rh-1a, prepared from ferrocenyl based ligand 1a or 1b and [(COD)RhCl]2, has been shown through kinetic studies to suffer from product inhibition. Enamine ester substrates have also been shown to be incompatible with the amine products of the reaction in methanol. In situ protection of the amine products with di-tert-butyl dicarbonate eliminates functional group incompatibility of ester substrates and eliminates product inhibition in the reaction.

Synthesis and Biological Evaluation of 6-Substituted 3-Aryl-2-methyl-4(3H)-pyrimidones

6-Substituted 3-aryl-2-methyl-4(3H)-pyrimidones (III) have been prepared by the reaction of N-arylacetamidines (II) with various diplorophiles like ethyl propiolate, ethyl tetrolate and ethyl phenylpropiolate.The structure of the products has been confirm