1802379-04-9

Basic information

• Product Name: TN023991
• Synonyms: TN023991
• CAS NO: 1802379-04-9
• Molecular Formula: C19H19ClFNO2
• Molecular Weight: 347.81
• EINECS: -0
• Mol File: 1802379-04-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TN023991(CAS DataBase Reference)
• NIST Chemistry Reference: TN023991(1802379-04-9)
• EPA Substance Registry System: TN023991(1802379-04-9)

Safety Data

• Hazardous Substances Data: 1802379-04-9(Hazardous Substances Data)

Upstream product

• 1562404-79-8 [(R)-1-(4-bromobenzyl)-2-(2,2,5-trimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester 
• 1394050-15-7 [(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester 
• 79561-82-3 (2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid 
• 62561-74-4 (2R)-2-amino-3-(4-bromophenyl)propanoic acid 

Downstream Products

• 1562404-57-2 (2S,4R)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid 
• 1562405-29-1 (2S,4R)-benzyl 4-((tert-butoxycarbonyl)amino)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-2-methylpentanoate 

Relevant articles and documents

CRYSTALLINE(2S,4R)-5-(5'-CHLORO-2'-FLUORO-[1,1'-BIPHENYL]-4-YL)-2-(ETHOXYMETHYL)-4-(3-HYDROXYISOXAZOLE-5-CARBOXAMIDO)-2-METHYLPENTANOIC ACID AND USES THEREOF

In one aspect, the invention relates to a crystalline form of the structure: or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crys

5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula (I): where R1, R2a, R2b, and R3-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compou