1807512-36-2

Basic information

• Product Name: Azido-PEG3-(CH2)3OH
• Synonyms: Azido-PEG3-(CH2)3OH;N3-PEG3-CH2CH2CH2OH
• CAS NO: 1807512-36-2
• Molecular Formula: C9H19N3O4
• Molecular Weight: 233.26486
• Mol File: 1807512-36-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in Water, DMSO, DCM, DMF
• CAS DataBase Reference: Azido-PEG3-(CH2)3OH(CAS DataBase Reference)
• NIST Chemistry Reference: Azido-PEG3-(CH2)3OH(1807512-36-2)
• EPA Substance Registry System: Azido-PEG3-(CH2)3OH(1807512-36-2)

Safety Data

• Hazardous Substances Data: 1807512-36-2(Hazardous Substances Data)

Usage

Description

Azido-PEG3-(CH2)3OH is a PEG (polyethylene glycol) linker that features a three-carbon chain connecting the PEG fragment to a hydroxyl (OH) group. This molecule is notable for its azide group, which can participate in click chemistry reactions with alkyne, BCN, and DBCO to form a stable triazole linkage. The presence of the hydroxyl group allows for further chemical modifications, such as derivatization or substitution with other reactive functional groups, making it a versatile building block in various applications.

Uses

Used in Bioconjugation and Drug Delivery:
Azido-PEG3-(CH2)3OH is used as a versatile linker for bioconjugation and drug delivery applications due to its ability to form stable triazole linkages through click chemistry. The hydroxyl group enables further functionalization, allowing for the attachment of drugs, targeting ligands, or other biomolecules to enhance the efficacy and specificity of drug delivery systems.
Used in Chemical Synthesis and Polymer Science:
In the field of chemical synthesis and polymer science, Azido-PEG3-(CH2)3OH is used as a building block for the creation of complex macromolecules and polymers. The azide group facilitates the formation of triazole linkages, which can be used to construct diverse polymer architectures with tailored properties.
Used in Materials Science:
Azido-PEG3-(CH2)3OH is employed as a component in the development of novel materials with specific properties, such as self-healing materials or stimuli-responsive materials. The click chemistry enabled by the azide group allows for the precise and efficient assembly of these materials at the molecular level.
Used in Pharmaceutical Research:
In pharmaceutical research, Azido-PEG3-(CH2)3OH is used as a key intermediate for the synthesis of drug candidates with improved pharmacokinetic properties. The PEGylation of drugs using this linker can enhance solubility, stability, and circulation time in the body, potentially leading to more effective therapeutics.
Used in Diagnostics and Imaging:
Azido-PEG3-(CH2)3OH is utilized as a component in the development of diagnostic and imaging agents. The ability to form stable triazole linkages with various imaging moieties allows for the creation of contrast agents or probes with enhanced targeting and imaging capabilities.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, given the versatility of Azido-PEG3-(CH2)3OH and its potential use in drug delivery and bioconjugation, it could also be employed in the development of anticancer agents. The molecule could be used to create targeted drug delivery systems or conjugates with enhanced antitumor activity and reduced side effects.