181128-25-6

Basic information

• Product Name: (S)-Boc-2-amino-4,4,4-trifluoro-butyric acid
• Synonyms: (S)-Boc-2-amino-4,4,4-trifluoro-butyric acid;(S)-Boc-2-amino-4,4,4-trifluoro-butyric acid≥ 98% (HPLC)
• CAS NO: 181128-25-6
• Molecular Formula: C₉H₁₄F₃NO₄
• Molecular Weight: 257.2069696
• Mol File: 181128-25-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 322.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.280±0.06 g/cm3(Predicted)
• PKA: 3.34±0.10(Predicted)
• CAS DataBase Reference: (S)-Boc-2-amino-4,4,4-trifluoro-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Boc-2-amino-4,4,4-trifluoro-butyric acid(181128-25-6)
• EPA Substance Registry System: (S)-Boc-2-amino-4,4,4-trifluoro-butyric acid(181128-25-6)

Safety Data

• Hazardous Substances Data: 181128-25-6(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Upstream product

• 610272-57-6 1,1-dimethylethyl [(1S)-3,3,3-trifluoro-1-(hydroxymethyl)propyl]carbamate 
• 610272-55-4 thiocarbonic acid O-(3-benzyloxy-2-tert-butoxycarbonylamino-1-trifluoromethyl-propyl) ester O-phenyl ester 
• 610272-53-2 (2R,3R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-4,4,4-trifluorobutan-3-ol 
• 610272-56-5 (2S)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-4,4,4-trifluorobutane 

Relevant articles and documents

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to address the metabolic liabilities of the Cat K inhibitor L-873724. Substituting P1 and modifying the P2 side chain led to a metabolically robust inhibitor with a long half-life in preclinical species. Odanacatib was more selective in whole cell assays than the published Cat K inhibitors balicatib and relacatib. Evaluation in dermal fibroblast culture showed minimal intracellular collagen accumulation relative to less selective Cat K inhibitors.