1817735-36-6

Basic information

• Product Name: Pyrene -PEG3-azide
• Synonyms: Pyrene -PEG3-azide
• CAS NO: 1817735-36-6
• Molecular Formula: C25H28N4O4
• Molecular Weight: 448.52
• Mol File: 1817735-36-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DMF, DCM
• CAS DataBase Reference: Pyrene -PEG3-azide(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrene -PEG3-azide(1817735-36-6)
• EPA Substance Registry System: Pyrene -PEG3-azide(1817735-36-6)

Safety Data

• Hazardous Substances Data: 1817735-36-6(Hazardous Substances Data)

Usage

Description

Pyrene-PEG3-azide is a versatile pyrene-labeled PEG (polyethylene glycol) linker that incorporates an azide group. This unique structure allows for Click Chemistry labeling with alkyne-containing molecules, effectively converting any molecule into a pyrene-bearing probe. The PEG linker provides enhanced solubility and stability, while the pyrene moiety offers fluorescence properties that can be exploited for various analytical and biological applications.

Uses

Used in Bioconjugation:
Pyrene-PEG3-azide is used as a bioconjugation agent for attaching pyrene to biomolecules such as proteins, peptides, and nucleic acids. The azide group facilitates the Click Chemistry reaction with alkyne-modified biomolecules, enabling the formation of stable covalent bonds and the creation of pyrene-labeled conjugates.
Used in Analytical Chemistry:
In the field of analytical chemistry, Pyrene-PEG3-azide is used as a fluorescent probe for detecting and quantifying various analytes. The pyrene moiety's fluorescence properties can be modulated by the local environment, making it suitable for sensing applications, such as monitoring changes in pH, polarity, or the presence of specific ions.
Used in Drug Delivery Systems:
Pyrene-PEG3-azide can be utilized in drug delivery systems as a component of polymeric carriers or nanoparticles. The PEG linker enhances the solubility and biocompatibility of the drug delivery system, while the pyrene label allows for tracking and monitoring the delivery vehicle's distribution and release profile in biological systems.
Used in Molecular Imaging:
In molecular imaging applications, Pyrene-PEG3-azide serves as a fluorescent imaging agent. The pyrene label can be attached to targeting moieties or contrast agents, enabling the visualization of specific biological processes or the detection of disease markers in vivo.
Used in Materials Science:
In materials science, Pyrene-PEG3-azide can be employed in the development of functional materials with pyrene-based properties. The azide group allows for the incorporation of pyrene into polymers, gels, or other materials through Click Chemistry, resulting in materials with tailored fluorescence, sensing, or self-assembly properties.
Overall, Pyrene-PEG3-azide is a multifunctional molecule with broad applications across various fields, including bioconjugation, analytical chemistry, drug delivery, molecular imaging, and materials science. Its unique combination of a pyrene label, PEG linker, and azide group makes it a valuable tool for the development of novel probes, sensors, and materials with diverse functionalities.