181931-55-5

Basic information

• Product Name: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester
• Synonyms: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester
• CAS NO: 181931-55-5
• Molecular Weight: 560.805
• Mol File: 181931-55-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester(181931-55-5)
• EPA Substance Registry System: 5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester(181931-55-5)

Safety Data

• Hazardous Substances Data: 181931-55-5(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 181931-54-4 4-(4-Fluoro-phenyl)-5-hydroxymethyl-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-46-4 2-(Diethoxy-phosphoryl)-3-[2-(4-fluoro-phenyl)-2-hydroxy-ethylsulfanyl]-4-methyl-pentanoic acid ethyl ester 
• 181931-47-5 2-(Diethoxy-phosphoryl)-3-[2-(4-fluoro-phenyl)-2-oxo-ethylsulfanyl]-4-methyl-pentanoic acid ethyl ester 
• 181931-49-7 5-Bromo-4-(4-fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-43-1 4-(4-Fluoro-phenyl)-2-isopropyl-2,5-dihydro-thiophene-3-carboxylic acid ethyl ester 
• 181931-44-2 4-(4-Fluoro-phenyl)-2-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 181931-41-9 S-acetyl-2-mercapto-4’-fluoroacetophenone 
• 181931-45-3 1-(4-Fluoro-phenyl)-2-mercapto-ethanol 
• 181931-42-0 mercapto-1-(4’-fluorophenyl)ethanone 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 173724-80-6 (E)-2-(Diethoxy-phosphoryl)-4-methyl-pent-2-enoic acid ethyl ester 

Relevant articles and documents

Synthesis of some highly functionalized thiophene-3-carboxylates and alcohols

Highly functionalized thiophenes are prepared by two methods. The first uses a lithium-halogen exchange reaction on a trisubstituted 5-bromothiophene 25 to generate the corresponding 5-lithiothiophene 26 which is then reacted with either dimethylformainide or formaldehyde to give the 5-formyl 28 or 5-hydroxymethylthiophene derivative 31 in good yields. These are further transformed to other tetrasubstituted thiophenes. The second method assembles the thiophene ring from three components: a benzyl mercaptan, an aldehyde, and a vinylphosphonate 10. Thus, the benzyl mercaptan is dilithiated then reacted with an appropriate aldehyde to afford a 2-mercapto-2-phenylethanol derivative 37. Michael addition of 37 to 10 followed by oxidation of the hydroxyl group furnishes ketophosphonate 39. An intramolecular Wittig-type reaction produces the thiophene skeleton.