182344-63-4Relevant articles and documents
Synthesis of micrococcinic acid
Ross Kelly,Jagoe,Gu
, p. 4263 - 4266 (1991)
The first synthesis of micrococcinic acid (2) is described. The five rings of 2 are assembled from monocyclic precursors using four palladium-catalyzed biaryl coupling reactions.
Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as the flexible linker
Pan, Xiaoyan,Dong, Jinyun,Shi, Yaling,Shao, Ruili,Wei, Fen,Wang, Jinfeng,Zhang, Jie
, p. 7050 - 7066 (2015/06/25)
Forty-two compounds (series 8, 9 and 10) incorporated with diacylated piperazine have been synthesized and evaluated as novel Bcr-Abl inhibitors based on 'six-atom linker'. Five of them, 8d, 8h, 8l, 10m and 10p, displayed potent Bcr-Abl inhibitory activity comparable with Imatinib. Moreover, compounds 8e, 10q, 10s, and 10u were potent Bcr-Abl inhibitors with IC50 values at the sub-micromolecular level. Most compounds exhibited moderate to high antiproliferative activity against K562 cells. In particular, compound 9e was the most promising Bcr-Abl inhibitor. Docking studies revealed that the binding modes of these compounds were similar with Imatinib. These compounds could be considered as promising lead compounds for further optimization.
Rhodium(III)-catalyzed oxidative olefination of pyridines and quinolines: Multigram-scale synthesis of naphthyridinones
Zhou, Jun,Li, Bo,Hu, Fang,Shi, Bing-Feng
supporting information, p. 3460 - 3463 (2013/07/26)
A Rh(III)-catalyzed oxidative olefination of pyridines and quinolines has been achieved. This method has a broad substrate scope and has been applied to the expeditious, multigram-scale synthesis of naphthyridinones.