18270-17-2Relevant articles and documents
Catalytic Decarboxylation of Silyl Alkynoates to Alkynylsilanes
Aoyagi, Keiya,Choi, Jun-Chul,Kawatsu, Takahiro,Matsumoto, Kazuhiro,Nakajima, Yumiko,Sato, Kazuhiko
supporting information, (2020/09/15)
Herein, we describe a decarboxylative approach to the preparation of alkynylsilanes. Treatment of a silyl alkynoate in N,N-dimethylformamide (DMF) at 80 °C in the presence of catalytic amounts of CuCl and PCy3 produced the corresponding alkynylsilane in excellent yield. The copper-catalyzed decarboxylation proceeded smoothly with low catalyst loadings (0.5 mol % of CuCl and 1.0 mol % of PCy3) under mild reaction conditions and is easily scalable to gram quantities.
TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE
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Paragraph 0702; 0703, (2016/12/22)
Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-α protein.
Reactions of 1,2-dihalocycloalkenes with alkali metals in presence of chlorotrimethylsilane. Reductive carbon-carbon bond cleavage in five membered homocyclic system
HariPrasad,Nagendrappa
, p. 3387 - 3396 (2007/10/02)
1,2-Dihalocyclopentenes on reaction with alkali metals and chlorotrimethylsilane in hydrocarbon or ether solvents produce silylated 1-pentynes by ring opening. Sodium metal and hydrocarbon solvents favour the cleavage most. Different mechanistic aspects are considered.