182748-72-7Relevant articles and documents
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Khan, Sajid,Zhang, Xuan,Lv, Dongwen,Zhang, Qi,He, Yonghan,Zhang, Peiyi,Liu, Xingui,Thummuri, Dinesh,Yuan, Yaxia,Wiegand, Janet S.,Pei, Jing,Zhang, Weizhou,Sharma, Abhisheak,McCurdy, Christopher R.,Kuruvilla, Vinitha M.,Baran, Natalia,Ferrando, Adolfo A.,Kim, Yong-mi,Rogojina, Anna,Houghton, Peter J.,Huang, Guangcun,Hromas, Robert,Konopleva, Marina,Zheng, Guangrong,Zhou, Daohong
, p. 1938 - 1947 (2019)
B-cell lymphoma extra large (BCL-XL) is a well-validated cancer target. However, the on-target and dose-limiting thrombocytopenia limits the use of BCL-XL inhibitors, such as ABT263, as safe and effective anticancer agents. To reduce
IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
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Paragraph 00222, (2017/07/05)
This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
HETEROARYL BUTANOIC ACID DERIVATIVES AS LTA4H INHIBITORS
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Page/Page column -32, (2015/07/07)
The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase (LTA4H). The present invention also relates to pharmaceutical compositions comprising said novel he