183008-31-3Relevant articles and documents
The synthesis and reactions of 4-(2- and 3-thienyl)-tetrahydroisoquinolines
Tupper, David E.,Hotten, Terrence M.,Prowse, William G.
, p. 1123 - 1129 (1996)
Tetrahydroisoquinoline derivatives substituted in the 4-position by either a 2- or 3-substituted thiophene ring have been synthesised. Simple electrophilic substitution reactions of these systems take place as expected in the α-position of the thiophene ring. Metalation reactions are more complex and take place at the benzylic 4-position of the tetrahydroisoquinoline nucleus in the case of the 2-substituted thiophene derivatives or at either the thiophene α-positions or the benzylic 4-position depending on the nature of the attacking electrophile in the case of the 3-substituted thiophene system.
