18305-96-9

Basic information

• Product Name: 3-(acetyloxy)-11-oxoolean-12-en-29-oic acid
• CAS NO: 18305-96-9
• Molecular Formula: C₃₂H₄₈O₅
• Molecular Weight: 512.7205
• Mol File: 18305-96-9.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 597°C at 760 mmHg
• Flash Point: 183.1°C
• Density: 1.14g/cm³
• Vapor Pressure: 8.52E-16mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 3-(acetyloxy)-11-oxoolean-12-en-29-oic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(acetyloxy)-11-oxoolean-12-en-29-oic acid(18305-96-9)
• EPA Substance Registry System: 3-(acetyloxy)-11-oxoolean-12-en-29-oic acid(18305-96-9)

Safety Data

• Hazardous Substances Data: 18305-96-9(Hazardous Substances Data)

Upstream product

• 471-53-4 enoxolone 
• 108-24-7 acetic anhydride 
• 53402-18-9 3β-acetoxy-11-dioxyglycyrrhetic acid 
• 1405-86-3 glycyrrhizin 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 1620133-40-5 N-(L-phenylalanine tert-butyl ester)-3β-acetyl-11-oxo-olean-12-en-18β-H-30-amide 
• 51298-47-6 N-(L-phenylalanine)-3β-hydroxy-11-oxo-olean-12-en-18β-H-30-amide 
• 1612838-70-6 (cyclohexylamino)-(cyclohexylimino)-methyl 3β-acetyloxy-11-oxo-olean-12-en-30-oate 

Relevant articles and documents

N-methylated diazabicyclo[3.2.2]nonane substituted triterpenoic acids are excellent, hyperbolic and selective inhibitors for butyrylcholinesterase

Triterpenoic acids (oleanolic, ursolic, betulinic, platanic and glycyrrhetinic acid) were acetylated and coupled with 1,3- or 1,4-diazabicyclo[3.2.2]nonanes to yield amides. Reaction of these amides with methyl iodide at the distal nitrogen of the bicyclic system gave the corresponding quaternary ammonium salts. These compounds were shown to act as excellent inhibitors of the enzyme butyrylcholinesterase (BChE) while being only weak inhibitors for acetylcholinesterase (AChE). Evaluation of the enzyme kinetics revealed these compounds to act as hyperbolic inhibitors for BChE while the results from molecular modeling gave an explanation for their selectivity between AChE and BChE.

Nitrogenous heterocyclic glycyrrhetinic acid derivatives, and preparation method and anti-influenza A virus application thereof

The invention discloses nitrogenous heterocyclic glycyrrhetinic acid derivatives, and a preparation method and an anti-influenza A virus application thereof. The glycyrrhetinic acid derivatives comprise a nitrogen heterocyclic ring. A series of the glycyrrhetinic acid derivatives with anti-IAV activity are synthesized. The glycyrrhetinic acid derivatives have strong inhibitory activity on the influenza A virus (IAV), and have obviously stronger inhibitory activity on the influenza A virus than a common positive drug ribavirin, so that the glycyrrhetinic acid derivatives can be used for preparing anti-IAV drugs, and have no side effects.

Pentacyclic triterpenoid glycyrrhetinic acid derivative as well as preparation method and application thereof

The invention discloses a pentacyclic triterpenoid glycyrrhetinic acid derivative which has a structure as shown in a general formula 1 or a formula 7 in the specification, wherein each substituent isdefined in detail in the specification. The invention also discloses application of the pentacyclic triterpenoid glycyrrhetinic acid derivative in preparation of anti-HCV drugs. Huh7 cytotoxic activity results show that the pentacyclic triterpenoid glycyrrhetinic acid derivative is low in cytotoxicity and has research value. In-vitro anti-HCVcc result shows that glycyrrhetinic acid has relativelyweak anti-HCVcc activity, but the pentacyclic triterpenoid glycyrrhetinic acid derivative has relatively good anti-HCV activity.