183500-70-1

Basic information

• Product Name: 1-(3-CHLORO-PHENYL)-PIPERAZIN-2-ONE
• Synonyms: 1-(3-CHLORO-PHENYL)-PIPERAZIN-2-ONE;1-(3-chlorophenyl)-2-piperazinone;1-(3-Chlorophenyl)Piperazin-2-one(HCl);1-(3-Chlorophenyl)-2-piperazinone HCl
• CAS NO: 183500-70-1
• Molecular Formula: C₁₀H₁₁ClN₂O
• Molecular Weight: 210.66
• Product Categories: pharmacetical
• Mol File: 183500-70-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 443.887 °C at 760 mmHg
• Flash Point: 222.255 °C
• Appearance: /
• Density: 1.268 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-CHLORO-PHENYL)-PIPERAZIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-PHENYL)-PIPERAZIN-2-ONE(183500-70-1)
• EPA Substance Registry System: 1-(3-CHLORO-PHENYL)-PIPERAZIN-2-ONE(183500-70-1)

Safety Data

• Hazardous Substances Data: 183500-70-1(Hazardous Substances Data)

Usage

General Description

1-(3-chloro-phenyl)-piperazin-2-one is a chemical compound belonging to the class of piperazin-2-one derivatives. It has a molecular formula C10H12ClN2O and a molecular weight of 214.67 g/mol. 1-(3-CHLORO-PHENYL)-PIPERAZIN-2-ONE has a piperazine ring containing a chlorine-substituted phenyl group and a keto group. It may have various applications in the pharmaceutical and chemical industries, including as a building block for the synthesis of diverse organic compounds and as a potential drug candidate. Its physical and chemical properties, as well as its potential biological activities, make it an interesting target for further research and development.

InChI:InChI=1/C10H11ClN2O/c11-8-2-1-3-9(6-8)13-5-4-12-7-10(13)14/h1-3,6,12H,4-5,7H2

Upstream product

• 183500-69-8 4-(tert-butoxycarbonyl)-1-(3-chlorophenyl)-2-piperazinone 
• 144-55-8 sodium hydrogencarbonate 
• 108-37-2 1-bromo-3-chlorobenzene 
• 183500-94-9 1-(3-chlorophenyl)-2-piperazinone hydrochloride 

Downstream Products

• 183499-56-1 1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone dihydrochloride 
• 183499-57-2 1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone 
• 476494-01-6 4-[3-(6-bromo-pyridin-3-ylmethyl)-3H-imidazol-4-ylmethyl]-1-(3-chloro-phenyl)-piperazin-2-one 
• 312936-83-7 4-(1-[(4-bromophenyl)methyl]imidazol-5-ylmethyl)-1-(3-chlorophenyl)piperazin-2-one 
• 742045-40-5 1-(4-bromobenzyl)-5-(chloromethyl)-1H-imidazole 

Relevant articles and documents

QUATERNARY LACTAM COMPOUND AND PHARMACEUTICAL USE THEREOF

A quaternary lactam compound of formula (I). The compound is used in the manufacture of a medicament for the treatment and/or prevention of thrombotic or thromboembolic disorders.

Method of treating cancer

The present invention relates to methods of treating cancer using a combination of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras