1835759-68-6

Basic information

• Product Name: 1,1,1-Trifluoroethyl-PEG2-azide
• Synonyms: 1,1,1-Trifluoroethyl-PEG2-azide
• CAS NO: 1835759-68-6
• Molecular Formula: C6H10F3N3O2
• Molecular Weight: 213.1577096
• Mol File: 1835759-68-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1,1-Trifluoroethyl-PEG2-azide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-Trifluoroethyl-PEG2-azide(1835759-68-6)
• EPA Substance Registry System: 1,1,1-Trifluoroethyl-PEG2-azide(1835759-68-6)

Safety Data

• Hazardous Substances Data: 1835759-68-6(Hazardous Substances Data)

Usage

Description

1,1,1-Trifluoroethyl-PEG2-azide is a versatile crosslinker that features an azide group, a trifluoroethyl group, and a hydrophilic PEG2 spacer. The azide group enables participation in Click Chemistry reactions with various reagents, such as alkynes, DBCO, and BCN. The PEG2 spacer enhances solubility in aqueous media, while the trifluoroethyl group facilitates reactions with primary amine groups in proteins, antibodies, and other molecules and surfaces.

Uses

Used in Bioconjugation:
1,1,1-Trifluoroethyl-PEG2-azide is used as a crosslinking agent for bioconjugation, allowing the selective and efficient attachment of proteins, antibodies, and other molecules to surfaces or other biomolecules. The trifluoroethyl group reacts with primary amine groups, enabling stable and specific conjugation.
Used in Drug Delivery Systems:
1,1,1-Trifluoroethyl-PEG2-azide is used as a component in drug delivery systems to improve the solubility and stability of therapeutic agents. The hydrophilic PEG2 spacer enhances the solubility of hydrophobic drugs, while the azide group can be utilized in Click Chemistry reactions to attach drugs to carriers or other targeting moieties.
Used in Surface Modification:
1,1,1-Trifluoroethyl-PEG2-azide is used as a surface modifier to introduce functional groups or biomolecules onto various surfaces, such as nanoparticles, sensors, or medical devices. The trifluoroethyl group can react with amine-containing surface coatings, allowing for the covalent attachment of PEGylated molecules or other functional groups.
Used in Click Chemistry:
1,1,1-Trifluoroethyl-PEG2-azide is used as a reactant in Click Chemistry reactions, enabling the rapid and efficient formation of stable covalent bonds between molecules. The azide group can participate in reactions with alkynes, DBCO, and BCN, allowing for the precise and modular assembly of complex molecular structures.