1835759-69-7

Basic information

• Product Name: 1-isothiocyanato-PEG4-Alcohol
• Synonyms: 1-isothiocyanato-PEG4-Alcohol
• CAS NO: 1835759-69-7
• Molecular Formula: C9H17NO4S
• Molecular Weight: 235.30058
• Mol File: 1835759-69-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-isothiocyanato-PEG4-Alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-isothiocyanato-PEG4-Alcohol(1835759-69-7)
• EPA Substance Registry System: 1-isothiocyanato-PEG4-Alcohol(1835759-69-7)

Safety Data

• Hazardous Substances Data: 1835759-69-7(Hazardous Substances Data)

Usage

Description

1-isothiocyanato-PEG4-Alcohol is a versatile crosslinker that features a hydroxyl group and an isothiocyanato group. The hydroxyl group allows for various chemical reactions to further modify the compound, while the isothiocyanate group, along with its linkage isomer thiocyanate, serves as a ligand in coordination chemistry. The hydrophilic PEG (polyethylene glycol) spacer enhances the solubility of the compound in aqueous media, making it suitable for a range of applications.

Uses

Used in Pharmaceutical Industry:
1-isothiocyanato-PEG4-Alcohol is used as a pharmaceutical intermediate for the synthesis of drug conjugates and prodrugs. Its hydroxyl and isothiocyanato groups enable the attachment of therapeutic agents, improving their solubility, stability, and bioavailability.
Used in Bioconjugation:
1-isothiocyanato-PEG4-Alcohol is used as a bioconjugation agent to link biological molecules, such as proteins, peptides, and nucleic acids, with other molecules or surfaces. The isothiocyanato group reacts with amines to form stable thiourea bonds, facilitating the attachment of biomolecules for applications like immunoassays, drug delivery, and biosensors.
Used in Coordination Chemistry:
1-isothiocyanato-PEG4-Alcohol is used as a ligand in coordination chemistry for the synthesis of metal complexes. The isothiocyanato group can coordinate with metal ions, forming stable complexes with potential applications in catalysis, materials science, and medicinal chemistry.
Used in Polymer Science:
1-isothiocyanato-PEG4-Alcohol is used as a monomer or crosslinking agent in polymer synthesis. The hydroxyl group can participate in polymerization reactions, while the isothiocyanato group can react with other functional groups to form crosslinked networks. This allows for the creation of hydrogels, polymer brushes, and other materials with tailored properties for applications in drug delivery, tissue engineering, and surface modification.