184174-80-9

Basic information

• Product Name: 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
• Synonyms: ART-CHEM-BB B000471;METHYL 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLATE;2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER;4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID, 2-AMINO-5,6-DIHYDRO-, METHYL ESTER;AKOS B000471;AKOS BBB/008;4H-Cyclopenta[b]thiophene-3-carboxylicacid,2-amino-5,6-dihydro-,methyl;2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIO
• CAS NO: 184174-80-9
• Molecular Formula: C₉H₁₁NO₂S
• Molecular Weight: 197.25
• Product Categories: AMINOACID;Thiophene
• Mol File: 184174-80-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 177°C
• Boiling Point: 378.6±42.0 °C at 760 mmHg
• Flash Point: 182.8±27.9 °C
• Appearance: /
• Density: 1.3±0.1 g/cm³
• Vapor Pressure: 6.2E-06mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: 2-8°C
• PKA: 0.52±0.20(Predicted)
• CAS DataBase Reference: 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER(184174-80-9)
• EPA Substance Registry System: 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER(184174-80-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 184174-80-9(Hazardous Substances Data)

Usage

Chemical Properties

Grey solid

Uses

Methyl 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate is an intermediate in synthesis of azo thiophene disperse dyes.

InChI:InChI=1/C9H11NO2S/c1-12-9(11)7-5-3-2-4-6(5)13-8(7)10/h2-4,10H2,1H3

Upstream product

• 120-92-3 cyclopentanone 
• 105-34-0 methyl 2-cyanoacetate 
• 67-56-1 methanol 
• 372-09-8 cyanoacetic acid 

Downstream Products

• 1240504-50-0 methyl 2-[(1-benzyl-5-oxo-4-trifluoromethyl-2-phenyl-4,5-dihydroimidazol-4-yl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate 
• 1268707-07-8 C₁₇H₁₄FN₃O₃S 
• 1268706-96-2 C₂₅H₂₂FN₃O₄S 
• 1268706-83-7 C₁₉H₁₈N₂O₅S 
• 1268706-70-2 C₁₆H₁₈N₂O₃S 

Relevant articles and documents

Microwave-assisted synthesis of 2-aminothiophene derivatives via improved gewald reactions

In this paper, a new and efficient method was developed to prepare 2-aminothiophene derivatives through improved Gewald reaction. Thirty-one final products were synthesized under microwave radiation for 30 min with 57%-95% isolated yields. All the product

SULFONYLUREA DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Azo dyes

The azo dyes relate to thiophene azo dyes of the general formula: where R1 is Cyano or C1-C5 alkoxy carbonyl; R2 is hydrogen, halogene, C1-C2 alkyl, phenyl, or substituted phenyl; and R3 is C1-C5 alkoxy carbonyl, C1-C4 alkanoyl, benzoyl, phenyl, alkyl substituted phenyl, or alkoxy phenyl; or R2 and R3 are fused cycloalkane with C3-C5.