18418-42-3

Basic information

• Product Name: Carbamodithioic acid, phenyl-, monosodium salt
• CAS NO: 18418-42-3
• Molecular Formula: C7H7NS2.Na
• Molecular Weight: 191.253
• Mol File: 18418-42-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Carbamodithioic acid, phenyl-, monosodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamodithioic acid, phenyl-, monosodium salt(18418-42-3)
• EPA Substance Registry System: Carbamodithioic acid, phenyl-, monosodium salt(18418-42-3)

Safety Data

• Hazardous Substances Data: 18418-42-3(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 62-53-3 aniline 
• 534-18-9 sodium trithiocarbonate 

Downstream Products

• 53278-51-6 S-(phenylthiocarbamoyl)thioglycolic acid 
• 53278-59-4 2-(Anilino-dithiocarbamyl)propionsaeure 
• 39184-83-3 thioacetic acid-(2-chloro-anilide) 
• 103-72-0 phenyl isothiocyanate 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 701-73-5 methyl N-phenyldithiocarbamate 
• 1137-01-5 2-cyano-N¹-phenyl-thiomalonamide 
• 884536-73-6 3,4-dihydro-4-oxo-2-phenyl-6-(phenylamino)-2H-1,3-thiazine-5-carbonitrile 
• 1137-65-1 3-hydroxy-5-phenylamino-isothiazol-4-carbonitrile 
• 77437-22-0 C₂₂H₁₉N₅OS 
• 731-52-2 2-hydrazino-3-phenyl-3H-quinazolin-4-one 
• 121662-02-0 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylquinazolin-4(3H)-one 
• 59342-38-0 4-phenyl-4,5-dihydrotetrazolo<1,2-a>-5-quinazolone 
• 67442-90-4 4-phenyl-5-oxo-1-thioxo-1,2,4,5-tetrahydro-s-triazolo<4,3-a>-quinazoline 

Relevant articles and documents

Amine-carbon disulfide promoted synthesis of novel benzo[e][1,3]thiazepin-5(1H)-one derivatives

In this paper, a simple method is introduced for the synthesis of novel 4-substituted-3-thioxo-3,4-dihydrobenzo[e][1,3]thiazepin-5(1H)-one derivatives. The synthesis is based on a two-step reaction of 2-methylbenzoic acid, an amine, and carbon disulfide. In the first step, 2-methylbenzoic acid reacts with sulfuric acid in ethanol, followed by the reaction with N-bromosuccinimide to produce ethyl 2-(bromomethyl)benzoate. Amine and carbon disulfide react in a separate flask in basic medium to give carbamodithioate salt. Carbamodithioate and ethyl 2-(bromomethyl)benzoate react together in dimethylformamide to produce the desired 4-substituted-3-thioxo-3,4-dihydrobenzo[e][1,3]thiazepin-5(1H)-one derivatives. The method is simple and fast and is applicable to a wide variety of substrates and gives the desired products in high isolated yields.

Anti-HIV, Antitubercular and Antibacterial Activities of Novel 3-(Substituted Quinazolinylamino)-2-phenyl quinazolin-4(3H)ones

In the present study, we have synthesized a series of novel 2-phenyl-3-(substituted quinazolinylamino)quinazolin-4(3H)-ones by the reaction of 3-(substituted)-2-hydrazinoquinazoline-4(3H)-ones with 2-phenyl-3,1-benzoxazin-4-one. The starting material 3-(substituted)-2-hydrazino-quinazolin-4(3H)-ones were synthesized from various primary amines. All the synthesized compounds were screened for their antitubercular, anti-HIV and antibacterial activity against different Gram-positive and Gram-negative strains by agar dilution method. Among the test compounds, 3-(4-nitrophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (BQZ6) and 3-(4-chlorophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (BQZ7) shown most potent antibacterial activity against E. coli, P. aeruginosa and S. aureus with the MIC of 3 μg/mL. The compound BQZ7 exhibited the antitubercular activity with the MIC of 25 μg/mL and anti-HIV activity with the MIC of 35.4 μg/mL against HIV1 and HIV2 and offers potential lead for further optimization and development to new antitubercular and anti-HIV agents. The results from this study confirm that the synthesized and biologically evaluated quinazolines showed promising antimicrobial, antitubercular and anti-HIV activities and are new scaffolds for antimicrobial activity.

Convenient Structural Diversity-Guided Synthesis of Functionalized Sulfur-Containing Heterocycles via α-Substituted Cyanoacetamides

A convenient molecular diversity-oriented synthesis of various functional sulfur-containing heterocyclic scaffolds mainly including isothiazole, 2H-1,3-thiazine, and thiazolidine via different methods from α-substituted cyanoacetamides is described. The target molecules have been identified on the basis of analytical spectral data, which may serve as useful structural subunits in the fields of drug discovery.