18437-67-7

Basic information

• Product Name: tert-butyl m-tolylcarbamate
• Synonyms: tert-butyl m-tolylcarbamate
• CAS NO: 18437-67-7
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.26888
• Product Categories: amine|carboxylic ester
• Mol File: 18437-67-7.mol
• Article Data: 26

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: tert-butyl m-tolylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl m-tolylcarbamate(18437-67-7)
• EPA Substance Registry System: tert-butyl m-tolylcarbamate(18437-67-7)

Safety Data

• Hazardous Substances Data: 18437-67-7(Hazardous Substances Data)

Usage

General Description

Tert-butyl m-tolylcarbamate is a complex organic chemical compound that is primarily utilized within the field of organic synthesis in chemical laboratories. It encompasses a group of reactive properties which make it valuable for creating an array of different substances and products. As denoted by its scientific classification, this chemical contains tert-butyl and m-tolyl groups attached to a carbamate functional group, resulting in its unique structure and properties. While its unique structure provides a range of utilities in various applications, it must be handled with care due to potential hazards associated with its use.

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 108-41-8 1-chloro-3-methylbenzene 
• 625-95-6 3-Iodotoluene 
• 591-17-3 meta-bromotoluene 
• 99-08-1 1-methyl-3-nitrobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 108-44-1 1-amino-3-methylbenzene 

Downstream Products

• 5198-45-8 N-(3-methylphenyl)oxazolidin-2-one 
• 29218-27-7 toloxatone 

Relevant articles and documents

Direct synthesis of oxazolidin-2-ones from tert-butyl allylcarbamate via halo-induced cyclisation

A novel synthetic pathway towards the 2-oxazolidinone derivatives involving the halo-induced cyclisation of tert-butyl allyl(phenyl)carbamate was successfully developed. Various halogenating reagents were evaluated under different reaction conditions for the reaction optimisation. Interestingly, the synthetic route to 2-oxazolidinone derivatives containing one halogen atom in the aliphatic site or two halogen atoms including the extra halogen atom substituted in the aryl group at the para position, were thoroughly established for all chloro-, bromo- and iodo compounds. Either halo-unsubstituted-aryl oxazolidinone or p-halo-substituted-aryl oxazolidinone could be selectively produced by selecting the appropriate choices of halogenated reagents and reaction conditions e.g. reaction time and temperature. Toloxatone, a commercial antidepressant, was successfully synthesized by using this developed method.

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, and chiral amines to their N-Boc-protected derivatives under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, and product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign.

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.