18440-00-1

Basic information

• Product Name: 2-Hydroxy-4-methoxyphenyl 2-methoxybenzyl ketone
• Synonyms: 2-Hydroxy-4-methoxyphenyl 2-methoxybenzyl ketone
• CAS NO: 18440-00-1
• Molecular Weight: 272.301
• Mol File: 18440-00-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Hydroxy-4-methoxyphenyl 2-methoxybenzyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-4-methoxyphenyl 2-methoxybenzyl ketone(18440-00-1)
• EPA Substance Registry System: 2-Hydroxy-4-methoxyphenyl 2-methoxybenzyl ketone(18440-00-1)

Safety Data

• Hazardous Substances Data: 18440-00-1(Hazardous Substances Data)

Upstream product

• 132593-11-4 3-(2,4-dimethoxy-phenyl)-2-(2-methoxy-phenyl)-3-oxo-propionitrile 
• 111798-01-7 3-(2,4-dimethoxy-phenyl)-2-(2-methoxy-phenyl)-3-oxo-propionic acid ethyl ester 
• 92549-46-7 1-(2,4-dihydroxy-phenyl)-2-(2-methoxy-phenyl)-ethanone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 2150-41-6 methyl 2, 4-dimethoxybenzoate 
• 108-46-3 recorcinol 
• 93-25-4 2-methoxyphenylacetic acid 

Downstream Products

• 19725-40-7 7-methoxy-3-(2-methoxyphenyl)-4H-chromen-4-one 
• 62536-79-2 2'-acetoxy-7-methoxy-isoflavone 
• 19725-41-8 2'-hydroxy-7-methoxy-isoflavone 
• 19725-36-1 7-hydroxy-3-(2-hydroxyphenyl)-4H-chromen-4-one 
• 5571-06-2 7,2'-Dimethoxyisoflavanone 
• 87538-47-4 1-(2-Hydroxy-4-methoxy-phenyl)-2-(2-methoxy-phenyl)-ethane-1,2-dione 
• 96682-36-9 3-Hydroxymethyl-7,2'-dimethoxyisoflavanone 
• 96682-30-3 2-Hydroxy-4-methoxyphenyl α-hydroxymethyl-2-methoxybenzyl ketone 
• 855624-01-0 2-hydroxy-7-methoxy-3-(2-methoxy-phenyl)-chroman-4-one 

Relevant articles and documents

Enantioselective Synthesis of Isoflavanones and Pterocarpans through a RuII-Catalyzed ATH-DKR of Isoflavones

Noyori-Ikariya RuII complexes promoted the one-pot C=C/C=O bonds reduction of isoflavones using sodium formate as the hydrogen source through Asymmetric Transfer Hydrogenation-Dynamic Kinetic Resolution (ATH-DKR). Due to the neutral conditions employed, isoflavones with different substituents at the 2’-position of B-ring (H, OH, OMe and Br) were successfully reduced. Ten cis-3-phenylchroman-4-ols were selectively obtained (>20 : 1 dr) in good yields (up to 86 %) and excellent enantioselectivities (up to >99 : 1 er). The synthetic applications of these chiral compounds were also demonstrated. Enantioenriched isoflavanones were obtained under mild metal-free oxidation of the cis-3-phenylchroman-4-ols while pterocarpans were synthesized by two strategies: an acid-catalyzed cyclization and a novel approach based on a Pd-catalyzed C?O intramolecular cross-coupling reaction.