18442-22-3

Basic information

• Product Name: 7-Bromo-4-chromanone
• Synonyms: 7-Bromo-4-chromanone;7-Bromo Chromonone;7-bromo-2,3-dihydrochromen-4-one;7-Bromo-2,3-dihydro-4H-1-benzopyran-4-one;7-broMo-3,4-dihydro-2H-1-benzopyran-4-one;7-BroMo-4-chroManone 97%;7-Bromochroman-4-one C9H7BrO2;7-bromo-2,3-dihydrobenzopyran-4-one
• CAS NO: 18442-22-3
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.05468
• EINECS: 1308068-626-2
• Product Categories: 18442-22-3
• Mol File: 18442-22-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 336.585 °C at 760 mmHg
• Flash Point: 157.361 °C
• Appearance: /
• Density: 1.622 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-Bromo-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-4-chromanone(18442-22-3)
• EPA Substance Registry System: 7-Bromo-4-chromanone(18442-22-3)

Safety Data

• Hazardous Substances Data: 18442-22-3(Hazardous Substances Data)

Usage

Uses

Used as a?intermediate for??R & D.

Synthesis

7-Bromochroman-4-one was synthesized by hydrogenation addition of 7-Bromo-benzopyrone catalyzed by Wilkinson's catalyst Rhodium( Ⅰ) tris( triphenylphosphine) chloride[Rh( PPh3)3Cl]. The structure was confirmed by1 H NMR and MS. The optimum reaction conditions for synthesizing 7-Bromochroman-4-one were as follows: 5 0. 329 mol,ethanol as the solvent,c( 5) =0. 4 mol·L- 1,4% mol Rh( PPh3)3Cl as the catalyst,under 0. 3 MPa of hydrogen pressure,at 70℃ for 20 h,the yield was 79. 8%.

InChI:InChI=1/C9H7BrO2/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-2,5H,3-4H2

Upstream product

• 890840-78-5 C₉H₆BrClO 
• 18386-03-3 3-(3-bromophenoxy)propionic acid 
• 168759-60-2 7-bromo-4H-benzopyran-4-one 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 591-20-8 3-Bromophenol 
• 1016736-70-1 3-(3-bromophenoxy)propanenitrile 
• 288067-35-6 4-bromo-2-hydroxy-benzonitrile 
• 876149-55-2 C₁₁H₁₂BrNO₂ 
• 945724-02-7 (E)-1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 1493-13-6 trifluorormethanesulfonic acid 

Downstream Products

• 1180671-97-9 7-bromo-3-amino-chroman-4-one hydrochloride 
• 1180671-95-7 (E,Z)-7-bromochroman-4-one O-tosyl oxime 

Relevant articles and documents

HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF

The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.

CHROMANE-SUBSTITUED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR TREATMENT OF VIRAL DISEASES

Disclosed are novel chromane-substituted tetracyclic compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, A', R2 R3, R4 and R5 are as defined in the description. Also disclosed are compositions comprising a chromane-substituted tetracyclic compound, and methods of using the chromane-substituted tetracyclic compounds for treating or preventing HCV infection in a patient.

ARYL SULFONAMIDES AS BLT1 ANTAGONISTS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leu