184589-36-4Relevant articles and documents
Synthesis of the cyclic heptapeptides Axinastatin 2 and Axinastatin 3
Pettit, George R.,Holman, Jeffrey W.,Boland, Gerard M.
, p. 2411 - 2416 (2007/10/03)
Practical total syntheses of axinastatins 2 2b and 3 2c were completed by employing Fmoc protection for the N-terminal, and tert-butyl ester blocking for the C-terminal, units of the amlno add and peptide intermediates. Generally, diethyl phosphorocyanidate proved effective for formation of the peptide bond, and in the one exception, asparagine, the o-nitrophenyl active ester proved to be useful. For the final cyclization reaction BOP-Cl was found especially effective. Copyright 1996 by the Royal Society of Chemistry.