18471-40-4

Basic information

• Product Name: 1-Benzyl-3-aminopyrrolidine
• Synonyms: N-BENZYL-3-AMINO PYRROLIDINE;1-BENZYLPYRROLIDIN-3-AMINE;1-Benzyl-3-pyrrolidinamine;1-BENZYL-3-AMINOPYRROLIDINE;3-AMINO-1-BENZYLPYRROLIDINE;N-1-Benzy-3-aminopyrrolidine;1-BENZYL-3-AMINOPYRROLIDINE 97+%;1-Benzyl-3-pyrrolidinylamine
• CAS NO: 18471-40-4
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.25814
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline;3-Aminopyrrolidines;3-Aminopyrrolidines (Racemic);Building Blocks;C11 to C30+;Chemical Synthesis;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 18471-40-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 261.5 °C at 760 mmHg
• Flash Point: >110°C
• Appearance: /
• Density: 1.024 g/mL at 25 °C
• Refractive Index: 1.5477
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.74±0.20(Predicted)
• CAS DataBase Reference: 1-Benzyl-3-aminopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-aminopyrrolidine(18471-40-4)
• EPA Substance Registry System: 1-Benzyl-3-aminopyrrolidine(18471-40-4)

Safety Data

• Hazard Codes: T;Xi,Xi,T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2810
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 18471-40-4(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3-aminopyrrolidine is a chemical compound with the molecular formula C13H18N2. It is an organic compound that belongs to the class of aminopyrrolidines, which are commonly used as key intermediates in the synthesis of pharmaceuticals and agrochemicals. This particular compound is characterized by a benzyl group attached to the nitrogen atom of a pyrrolidine ring, along with an amino group at the third position of the ring. 1-Benzyl-3-aminopyrrolidine has potential applications in the field of medicinal chemistry, as it can serve as a building block for the synthesis of diverse bioactive compounds with potential therapeutic properties. Its chemical structure and reactivity make it a valuable precursor for the development of new pharmaceutical agents, making it an important compound in drug discovery and development.

Upstream product

• 66832-28-8 1-benzyl-3-(hydroxyimino)pyrrolidine 
• 99735-30-5 N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 
• 118354-71-5 (S)-methanesulfonic acid 1-benzylpyrrolidin-3-yl ester 
• 368429-72-5 1-benzyl-5-oxo-pyrrolidine-3-carbohydrazide 
• 116041-19-1 1-benzyl 5-oxo-pyrrolidine-3-carboxamide 
• 51535-00-3 methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 
• 368429-69-0 4-amino 1-benzylpyrrolidin-2-one 

Downstream Products

• 96901-81-4 5-bromo-2,4-dimethoxy-N-(1-benzyl-3-pyrrolidinyl)benzamide 
• 61694-71-1 N-(1-benzyl-3-pyrrolidinyl)-4-amino-5-chloro-2-methoxybenzamide 
• 73328-60-6 N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylaminobenzamide 
• 61694-77-7 N-(1-benzyl-3-pyrrolidinyl)-5-chloro-4-dimethylamino-2-methoxybenzamide 
• 78775-22-1 N-(1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-ethylamino-2-methoxy-benzamide 
• 78784-41-5 N-(1-Benzyl-pyrrolidin-3-yl)-5-chloro-4-formylamino-2-methoxy-benzamide 
• 78775-26-5 4-Acetylamino-N-(1-benzyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-benzamide 
• 78775-24-3 4-Benzylamino-N-(1-benzyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-benzamide 
• 72412-41-0 2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-3-yl)-amide; compound with oxalic acid 
• 212192-46-6 N-(1-benzyl-pyrrolidin-3-yl)-4-iodo-benzamide 

Relevant articles and documents

Synthesis method of 3-aminopyrrolidine dihydrochloride

The invention discloses a synthetic method of 3-aminopyrrolidine dihydrochloride. The synthetic method comprises the following steps: preparing benzyl-(3-ethoxy-3-alkenyl)-(1-vinyl ethoxy methyl) amine liquid; preparation of a 1-benzyl-3-pyrrolidone solution; preparation of a 1-benzyl-3-aminopyrrolidine solution; preparing a 1-benzyl-3-aminopyrrolidine salt; preparing a 3-aminopyrrolidine solution; the yield and purity of the 3-aminopyrrolidine dihydrochloride are improved by controlling the activity of the reaction main materials of each part in a segmented manner and carrying out a directional hydrogenation manner.

HETEROARYL COMPOUNDS AND THEIR USE AS MER INHIBITORS

Compounds of formula (I) [Formula should be inserted here] and a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, R4, R5, R6, R7, R24, X, L, n and p are as defined in the specification, are useful for treating or preventing Mer tyrosine kinase receptor modulated disease or conditions. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Tetracyclic benzimidazole derivatives and combinatorial libraries thereof

The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.