185105-98-0 Usage
Description
Acotiamide INT, also known as Ethyl 2-(2,4,5-Trimethoxybenzamido)thiazole-4-carboxylate, is an impurity of Acotiamide (A190260). Acotiamide is an acetylcholinesterase inhibitor that has been demonstrated to stimulate gastric motility and improve gastric motility dysfunction in rats. It is characterized by its ability to enhance meal-related symptoms of functional dyspepsia.
Uses
Used in Pharmaceutical Industry:
Acotiamide INT is used as an impurity in the development of Acotiamide, an acetylcholinesterase inhibitor, for the treatment of gastric motility dysfunction and functional dyspepsia. Its presence in the compound contributes to the overall effectiveness of Acotiamide in improving meal-related symptoms and promoting gastric motility.
Used in Research and Development:
Acotiamide INT is used as a research compound for studying the effects of Acotiamide on gastric motility and functional dyspepsia. This helps in understanding the mechanisms of action and potential applications of Acotiamide in the treatment of gastrointestinal disorders.
Used in Quality Control:
Acotiamide INT is used in the quality control process of Acotiamide production to ensure the purity and efficacy of the final product. By monitoring the levels of this impurity, manufacturers can maintain the desired therapeutic effects and safety profile of Acotiamide.
Check Digit Verification of cas no
The CAS Registry Mumber 185105-98-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,1,0 and 5 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 185105-98:
(8*1)+(7*8)+(6*5)+(5*1)+(4*0)+(3*5)+(2*9)+(1*8)=140
140 % 10 = 0
So 185105-98-0 is a valid CAS Registry Number.
185105-98-0Relevant articles and documents
Preparation method of acotiamide hydrochloride impurity
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Paragraph 0020; 0022, (2020/08/30)
The invention discloses a preparation method of an acotiamide hydrochloride impurity, which comprises the following steps: carrying out acylating chlorination on raw material 2, 4, 5-trimethoxybenzoicacid to obtain 2, 4, 5-trimethoxybenzoyl chloride, and
A hydrochloric acid arab league tests for the amine intermediate and its synthesis process and application
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Paragraph 0029-0048, (2019/04/04)
The invention provides an acotiamide hydrochloride intermediate, and a synthesis technique and application thereof, belonging to the technical field of drug synthesis. The synthesis technique comprises the following steps: (1) mixing 2,4,5-trimethoxy benz
Preparation method of acotiamide intermediate
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Paragraph 0063; 0064, (2016/10/10)
The invention belongs to the field of medicines, and concretely relates to a preparation method of an acotiamide intermediate. The method comprises the following steps: preparing acyl chloride from 2,4,5-trimethoxybenzoic acid, condensing acyl chloride an