185225-84-7

Basic information

• Product Name: Cyclopropanamine,2-fluoro-,(1S,2R)-,4-methylbenzenesulfonate(9CI)
• Synonyms: Cyclopropanamine,2-fluoro-,(1S,2R)-,4-methylbenzenesulfonate(9CI);(1S,2R)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate (1:1);(1S,2R)-2-fluorocyclopropanamine 4-methylbenzenesulfonate;Sitafloxacin Impurity 10
• CAS NO: 185225-84-7
• Molecular Formula: C10H14FNO3S
• Molecular Weight: 247.29
• Mol File: 185225-84-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanamine,2-fluoro-,(1S,2R)-,4-methylbenzenesulfonate(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanamine,2-fluoro-,(1S,2R)-,4-methylbenzenesulfonate(9CI)(185225-84-7)
• EPA Substance Registry System: Cyclopropanamine,2-fluoro-,(1S,2R)-,4-methylbenzenesulfonate(9CI)(185225-84-7)

Safety Data

• Hazardous Substances Data: 185225-84-7(Hazardous Substances Data)

Usage

General Description

Cyclopropanamine, 2-fluoro, (1S,2R)-, 4-methylbenzenesulfonate(9CI) is a chemical compound with the molecular formula C11H15FNO3S. It is a sulfonate ester of cyclopropanamine with a 2-fluoro substituent and an (1S,2R) configuration. Cyclopropanamine,2-fluoro-,(1S,2R)-,4-methylbenzenesulfonate(9CI) is commonly used in organic synthesis as a reagent for various chemical reactions. Its unique structure and properties make it a useful intermediate in the pharmaceutical and agrochemical industries. Additionally, it is known to have potential applications in the development of new drugs and chemical compounds.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 156481-81-1 (R)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5,5-triphenyl-oxazolidin-2-one 
• 167073-09-8 tert-butyl N-[(1S,2R)-2-fluorocyclopropyl]carbamate 
• 142977-41-1 benzyl N-diphenylmethyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 142977-39-7 benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>-N-(1-phenylethyl)carbamate 
• 598-67-4 1,1,2-tribromo-2-fluoroethane 
• 108-59-8 malonic acid dimethyl ester 
• 127199-16-0 tert-butyl N-<(1R,2S)-2-fluorocyclopropyl>carbamate 
• 142977-51-3 (4R,5S)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5-diphenyl-oxazolidin-2-one 

Downstream Products

• 141042-21-9 (-)-cis-2-fluorocyclopropylamine hydrochloride 

Relevant articles and documents

Sitafloxacin three membered ring intermediate preparation method

The invention discloses a preparation method for a three-membered ring intermediate of sitafloxacin hydrate. The preparation method comprises the following steps: dimethyl malonate and 1,1,2-tribromo-2-fluoroethane react to synthesize a solid A, the solid A is subjected to debromination to prepare an oily liquid B, the oily liquid B is subjected to branched chain removal to prepare a solid C, the solid C is hydrolyzed to prepare a solid D, the solid D is subjected to chiral resolution with L-leucinamide and reduced to prepare a solid F, the solid F is introduced to an amino group and combined with p-toluenesulfonic acid to prepare the three-membered ring intermediate of sitafloxacin hydrate. The preparation method has fewer steps for preparing the three-membered ring intermediate of sitafloxacin hydrate, unnecessary isomer is separated by one step with the chiral resolution method, the product yield and purity are higher, and scale production is easier.

Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid

A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopro

Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution

The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul