185545-90-8

Basic information

• Product Name: (R)-1-(2-Fluorophenyl)ethylamine
• Synonyms: R-OF-PEM;(R)-1-(2-FLUOROPHENYL)ETHYLAMINE;(R)-1-(2-FLUOROPHENYL)ETHANAMINE;Benzenemethanamine, 2-fluoro-alpha-methyl-, (R)- (9CI);Benzenemethanamine, 2-fluoro-α-methyl-, (αR)-;(1R)-1-(2-Fluorophenyl)ethylamine;(1R)-1-(2-fluorophenyl)ethanamine;Benzenemethanamine,2-fluoro-a-methyl-, (aR)-
• CAS NO: 185545-90-8
• Molecular Formula: C8H10FN
• Molecular Weight: 139.17
• Product Categories: HALIDE
• Mol File: 185545-90-8.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 179.77 °C at 760 mmHg
• Flash Point: 70.242 °C
• Appearance: /
• Density: 1.063 g/cm³
• Vapor Pressure: 0.926mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.62±0.10(Predicted)
• CAS DataBase Reference: (R)-1-(2-Fluorophenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(2-Fluorophenyl)ethylamine(185545-90-8)
• EPA Substance Registry System: (R)-1-(2-Fluorophenyl)ethylamine(185545-90-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 185545-90-8(Hazardous Substances Data)

Usage

General Description

(R)-1-(2-Fluorophenyl)ethylamine, also known as 2-Fluoroamphetamine, is a chemical compound with a formula of C8H10FN. It is a substituted amphetamine with a fluorine atom attached to the phenyl ring. (R)-1-(2-Fluorophenyl)ethylamine is a psychoactive drug that acts as a releasing agent for serotonin, norepinephrine, and dopamine. It has been researched for its potential use in treating depression, anxiety, and other mood disorders. However, it is also known for its potential for abuse and is classified as a controlled substance in many countries. The compound has also been studied for its potential neurotoxic effects on the brain, particularly in relation to the release of serotonin. Overall, (R)-1-(2-Fluorophenyl)ethylamine is a compound of interest in the fields of pharmacology and neuroscience for its dual potential as a therapeutic agent and a drug of abuse.

InChI:InChI=1/C8H10FN/c1-6(10)7-4-2-3-5-8(7)9/h2-6H,10H2,1H3

Upstream product

• 130562-16-2 (αS,1'S)-N-(1-Phenylethyl)-2-fluoro-α-methylphenylmethylamine 
• 2836-82-0 (o-fluorophenyl)acetone 
• 326-62-5 2-fluorophenyl acetonitrile 
• 74788-44-6 1-(2-fluorophenyl)ethanamine 
• 185527-04-2 N-[1-(2-Fluoro-phenyl)-ethyl]-oxalamic acid octyl ester 
• 1019558-76-9 C₁₅H₁₆FN 
• 864263-83-2 1-(2-fluorophenyl)ethanamine hydrochloride 
• 1332832-14-0 (S)-1-(2-fluorophenyl)ethan-1-amine hydrochloride 
• 820208-98-8 C₈H₆O₄*C₁₆H₁₈FN 
• 130562-15-1 [1-(2-Fluoro-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine 
• 445-27-2 2'-Fluoroacetophenone 
• 444643-06-5 [1-(3-Fluoro-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 124-20-9 N-(3-aminopropyl)-1,4-diaminobutane 

Downstream Products

• 1105678-25-8 3-{[1-(2-fluorophenyl)ethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione 
• 1332827-96-9 (S)-2,2,2-trifluoro-N-(1-(2-(fluoro)phenyl)ethyl)acetamide 
• 445-27-2 2'-Fluoroacetophenone 
• 1000922-53-1 1-(2-chloro-6-fluorophenyl)ethan-1-amine 

Relevant articles and documents

Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model

Thirty-six novel threoninamide carbamate derivatives were designed and synthesised using active fragment-based pharmacophore model. Antifungal activities of these compounds were tested against Oomycete fungi Phytophthora capsici in vitro and in vivo. Interestingly, compound I-1, I-2, I-3, I-6 and I-7 exhibited moderate control effect (>50%) against Pseudoperonospora cubensis in greenhouse at 6.25 μg/mL, which is better than that of control. Meanwhile most of these compounds exhibited significant inhibitory against P. capsici. The other nine fungi were also tested. More importantly, some compounds exhibited remarkably high activities against Sclerotinia sclerotiorum, P. piricola and R. solan in vitro with EC50 values of 3.74–9.76 μg/mL. It is possible that the model is reliabile and this method can be used to discover lead compounds for the development of fungicides.

GPhos Ligand Enables Production of Chiral N-Arylamines in a Telescoped Transaminase-Buchwald-Hartwig Amination Cascade in the Presence of Excess Amine Donor

The combination of biocatalysis and chemocatalysis can be more powerful than either technique alone. However, combining the two is challenging due to typically very different reaction conditions. Herein, chiral N-aryl amines, key features of many active pharmaceutical ingredients, are accessed in excellent enantioselectivity (typically>99.5 % ee) by combining transaminases with the Buchwald-Hartwig amination. By employing a bi-phasic buffer-toluene system as well as the ligand GPhos, the telescoped cascade proceeded with up to 89 % overall conversion in the presence of excess alanine. No coupling to alanine was observed.

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.