18619-72-2

Basic information

• Product Name: 2-[[2-(Diethylamino)ethyl]thio]-3-phenylquinazolin-4(3H)-one
• Synonyms: 2-[[2-(Diethylamino)ethyl]thio]-3-phenylquinazolin-4(3H)-one
• CAS NO: 18619-72-2
• Molecular Formula: C₂₀H₂₃N₃OS
• Molecular Weight: 353.4811
• Mol File: 18619-72-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 497.4°Cat760mmHg
• Flash Point: 254.6°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 4.95E-10mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 2-[[2-(Diethylamino)ethyl]thio]-3-phenylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[2-(Diethylamino)ethyl]thio]-3-phenylquinazolin-4(3H)-one(18619-72-2)
• EPA Substance Registry System: 2-[[2-(Diethylamino)ethyl]thio]-3-phenylquinazolin-4(3H)-one(18619-72-2)

Safety Data

• Hazardous Substances Data: 18619-72-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H23N3OS/c1-3-22(4-2)14-15-25-20-21-18-13-9-8-12-17(18)19(24)23(20)16-10-6-5-7-11-16/h5-13H,3-4,14-15H2,1-2H3

Upstream product

• 18741-24-7 2-mercapto-3-phenyl-3H-quinazolin-4-one 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 100-35-6 2-(diethylamino)ethyl chloride 

Relevant articles and documents

Synthesis, properties, and mass-spectrometric fragmentation of 2-thio derivatives of 3-arylquinazolin-4-ones

We have studied the reactions of alkylation, oxidation, and hydrolysis of 3-aryl-2-thioxoquinazolin-4-ones. Alkylation in an alkaline medium occurs exclusively at the sulfur atom. Oxidation by hydrogen peroxide leads to formation of 3-arylquinazoline-2,4-diones. The latter are also obtained in base or acid hydrolysis of the synthesized S-alkyl derivatives. When 3-aryl-2-thioxoquinazolin-4-ones are reacted with iodine, we obtain the disulfides, while the reaction with chlorine in hydrochloric acid leads to 2-chloroquinazolin-4-ones. Studying the mass spectrometric behavior of the compounds obtained made it possible to observe in the gas phase ring-chain isomerization of the heterocyclic ring, and also S-N migration of the propargyl radical in molecular ions of the S-propargyl derivatives.