18621-29-9 Usage
Description
(2,2-DIMETHOXY-PROPOXY)-BENZENE, also known as DMPB, is a chemical compound with the molecular formula C11H16O3. It features a benzene ring with a propoxy group attached at the 2,2-positions and two methoxy groups attached to the propoxy group. This clear, colorless liquid has a mild, sweet odor and is considered to be low in toxicity. DMPB is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of fragrances and flavors.
Uses
Used in Pharmaceutical Industry:
(2,2-DIMETHOXY-PROPOXY)-BENZENE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and enhance their efficacy.
Used in Agrochemical Industry:
(2,2-DIMETHOXY-PROPOXY)-BENZENE is used as an intermediate in the synthesis of agrochemicals to help create effective products for agricultural applications.
Used in Fragrance and Flavor Industry:
(2,2-DIMETHOXY-PROPOXY)-BENZENE is used as a component in the production of fragrances and flavors due to its mild, sweet odor, adding to the sensory qualities of these products.
Check Digit Verification of cas no
The CAS Registry Mumber 18621-29-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,2 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18621-29:
(7*1)+(6*8)+(5*6)+(4*2)+(3*1)+(2*2)+(1*9)=109
109 % 10 = 9
So 18621-29-9 is a valid CAS Registry Number.
18621-29-9Relevant articles and documents
Palladium-Catalyzed C(sp3)?H Arylation of Primary Amines Using a Catalytic Alkyl Acetal to Form a Transient Directing Group
St John-Campbell, Sahra,Ou, Alex K.,Bull, James A.
supporting information, p. 17838 - 17843 (2018/11/23)
C?H Functionalization of amines is a prominent challenge due to the strong complexation of amines to transition metal catalysts, and therefore typically requires derivatization at nitrogen with a directing group. Transient directing groups (TDGs) permit C?H functionalization in a single operation, without needing these additional steps for directing group installation and removal. Here we report a palladium catalyzed γ-C?H arylation of amines using catalytic amounts of alkyl acetals as transient activators (e.g. commercially available (2,2-dimethoxyethoxy)benzene). This simple additive enables arylation of amines with a wide range of aryl iodides. Key structural features of the novel TDG are examined, demonstrating an important role for the masked carbonyl and ether functionalities. Detailed kinetic (RPKA) and mechanistic investigations determine the order in all reagents, and identify cyclopalladation as the turnover limiting step. Finally, the discovery of an unprecedented off-cycle free-amine directed ?-cyclopalladation of the arylation product is reported.
