18640-58-9

Basic information

• Product Name: 4'-BROMO-3'-NITROACETOPHENONE
• Synonyms: 4'-BROMO-3'-NITROACETOPHENONE;4-BROMO-3-NITROACETOPHENONE;1-(4-BROMO-3-NITROPHENYL)ETHAN-1-ONE;1-(4-BROMO-3-NITROPHENYL)ETHANONE;3-Nitro-4-bromoacetophenone;Acetophenone, 4'-bromo-3'-nitro-;Ethanone, 1-(4-bromo-3-nitrophenyl)-;4'-Bromo-3'-nitroacetophenone, 99+%
• CAS NO: 18640-58-9
• Molecular Formula: C₈H₆BrNO₃
• Molecular Weight: 244.04
• EINECS: 242-469-6
• Product Categories: Aromatic Ketones (substituted);C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 18640-58-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 117-121 °C(lit.)
• Boiling Point: 275.4℃
• Flash Point: 120.4℃
• Appearance: White to slightly yellow/Amorphous Powder
• Density: 1.637
• Refractive Index: 1.6090 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2050098
• CAS DataBase Reference: 4'-BROMO-3'-NITROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-3'-NITROACETOPHENONE(18640-58-9)
• EPA Substance Registry System: 4'-BROMO-3'-NITROACETOPHENONE(18640-58-9)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 18640-58-9(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow amorphous powder

General Description

4′-Bromo-3′-nitroacetophenone is an electron deficient acetophenone derivative.

Upstream product

• 99-90-1 para-bromoacetophenone 
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• 108-86-1 bromobenzene 

Downstream Products

• 30877-80-6 1-(3-nitro-4-(piperidin-1-yl)phenyl)ethanone 
• 6322-56-1 4'-hydroxy-3'-nitroacetophenone 
• 857565-30-1 1-[4-(4-dimethylamino-anilino)-3-nitro-phenyl]-ethanone 
• 131705-96-9 N-(2-nitro-4-acetylphenyl)phenylglycine 
• 37429-16-6 2-Nitro-4-acetyl-N-(2-dimethylamino)-ethylanilin 
• 15452-09-2 2-Nitro-4-acetyl-N-(2-diethylaminoethyl)-anilin 
• 37429-18-8 2-Nitro-4-acetyl-N-(3-dimethylaminopropyl)-anilin 
• 37429-19-9 2-Nitro-4-acetyl-N-(3-diethylaminopropyl)-anilin 
• 119426-64-1 6-acetyl-2-phenylquinoxaline 
• 131705-98-1 6-acetyl-2-phenylquinoxalin-3(4H)one 
• 131705-99-2 6-acetyl-3-chloro-2-phenylquinoxaline 
• 131706-01-9 methyl-(2-phenylquinoxalin-6-yl)ketoxime 
• 131706-05-3 1-(4-Oxy-2-phenyl-quinoxalin-6-yl)-ethanone 
• 131706-00-8 6-acetyl-2-phenyl-1,2,3,4-tetrahydroquinoxaline 

Relevant articles and documents

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.

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