186519-89-1

Basic information

• Product Name: 4-CHLORO-7-(PHENYLSULFONYL)-7H-PYRROLO[2,3-D]PYRIMIDINE
• Synonyms: 4-CHLORO-7-(PHENYLSULFONYL)-7H-PYRROLO[2,3-D]PYRIMIDINE;7-(benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine;7-(benzenesulfonyl)-4-chloropyrrolo[2,3-d]pyrimidine
• CAS NO: 186519-89-1
• Molecular Formula: C₁₂H₈ClN₃O₂S
• Molecular Weight: 293.73
• Mol File: 186519-89-1.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 502.4±53.0 °C(Predicted)
• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.81±0.30(Predicted)
• CAS DataBase Reference: 4-CHLORO-7-(PHENYLSULFONYL)-7H-PYRROLO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-7-(PHENYLSULFONYL)-7H-PYRROLO[2,3-D]PYRIMIDINE(186519-89-1)
• EPA Substance Registry System: 4-CHLORO-7-(PHENYLSULFONYL)-7H-PYRROLO[2,3-D]PYRIMIDINE(186519-89-1)

Safety Data

• Hazardous Substances Data: 186519-89-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine is a chemical compound with the molecular formula C15H9ClN4O2S. It is a heterocyclic organic compound that contains a pyrrolopyrimidine core structure. This chemical is known for its potential use in pharmaceutical research and drug development. It has been studied for its potential biological activities and therapeutic applications, particularly in the treatment of diseases such as cancer and inflammation. Its unique structure and properties make it a valuable target for further investigation and potential use in the development of new medications.

Upstream product

• 3680-71-5 7-deazahypoxanthine 
• 3680-71-5 Allopurinol 
• 98-09-9 benzenesulfonyl chloride 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 16019-34-4 7-benzyl-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 
• 876343-10-1 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 
• 1643962-37-1 (R)-6-iodo-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1637569-25-5 C₁₃H₁₀FIN₄ 
• 1643962-38-2 (S)-2-((6-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-phenylethan-1-ol 
• 1637437-41-2 C₁₄H₁₂FIN₄O 
• 1637438-20-0 C₂₁H₂₀N₄O 
• 1637438-32-4 C₂₀H₁₈N₄O 
• 1637438-64-2 C₂₀H₁₈N₄O 
• 1637569-24-4 C₂₁H₂₀N₄O 
• 497841-30-2 {3-[4-((R)-1-phenyl-ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-phenyl}-methanol 
• 497841-27-7 {4-[4-((R)-1-phenyl-ethylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-phenyl}-methanol 
• 1637437-71-8 (R)-3-methoxy-4-(4-((1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzaldehyde 
• 1637437-39-8 (R)-(3-methoxy-4-(4-((1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)methanol 

Relevant articles and documents

Optochemical control of transcription by the use of 7-deaza-adenosine-based diarylethenes

Out of nine different 7-deaza-adenosine diarylethenes, we identified a high-performance photoswitch, suitable for the synthesis of photochromic DNA. By using solid phase synthesis, a photoresponsive T7 promotor was generated which allowed reversibly modulating the rate of enzymatic RNA synthesisin vitro.

IRREVERSIBLE INHIBITORS OF MENIN-MLL INTERACTION

Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

3-HYDROXY-N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)PYRROLIDINE-1-CARBOXAMIDE DERIVATIVES

The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions compris