186588-84-1

Basic information

• Product Name: METHYL 3-(BENZYLOXY)-2-THIOPHENECARBOXYLATE
• Synonyms: METHYL 3-(BENZYLOXY)-2-THIOPHENECARBOXYLATE;Methyl 3-(benzyloxy)thiophene-2-carboxylate
• CAS NO: 186588-84-1
• Molecular Formula: C₁₃H₁₂O₃S
• Molecular Weight: 248.3
• Mol File: 186588-84-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 67-68°C
• Appearance: /
• CAS DataBase Reference: METHYL 3-(BENZYLOXY)-2-THIOPHENECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-(BENZYLOXY)-2-THIOPHENECARBOXYLATE(186588-84-1)
• EPA Substance Registry System: METHYL 3-(BENZYLOXY)-2-THIOPHENECARBOXYLATE(186588-84-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 186588-84-1(Hazardous Substances Data)

Upstream product

• 5118-06-9 methyl 3-hydroxy-2-thiophenecarboxylate 
• 100-39-0 benzyl bromide 

Downstream Products

• 186588-86-3 Benzyl 3-(3-benzyloxythiophen-2-yl)-3-oxopropionate 
• 62521-44-2 2-<3-(α-Hydroxybenzyl)-2-thienyl>-4,4-dimethyl-2-oxazolin 

Relevant articles and documents

Rationalisation of patterns of competing reactivity by x-ray structure determination: Reaction of isomeric (benzyloxythienyl)oxazolines with a base

Three isomeric (benzyloxythienyl)oxazolines 9, 11 and 13 have been prepared and are found, upon treatment with a strong base, to undergo either Wittig rearrangement or intramolecular attack of the benzylic anion on the oxazoline function to give products derived from cleavage of the initially formed 3-aminothienofuran products. This pattern of reactivity is directly linked to the distance between the two reactive groups as determined by X-ray diffraction, with the greatest distance in 11 leading to exclusive Wittig rearrangement, the shortest distance in 13 giving exclusively cyclisation-derived products, and the intermediate distance in 9 leading to both processes being observed. The corresponding N-butyl amides were also obtained in two cases and one of these undergoes efficient Wittig rearrangement leading to a thieno[2,3-c]pyrrolone product.

PYRAZOLE COMPOUNDS AND USE THEREOF

The pyrazole compound of the present invention is represented by the following general formula (I). The pyrazole compound of the present invention or a salt thereof or a solvate thereof potently inhibits liver glycogen phosphorylase, and, therefore, is useful as a therapeutic or prophylactic agent for diabetes. wherein each symbol denotes as described in the specifications.

Synthesis and anthelmintic activity of 7-hydroxy-5-oxo-5H-thieno[3,2- b]pyran-6-carboxanilides and -6-thiocarboxanilides

7-Hydroxy-5-oxo-5H-thieno[3,2-b]pyran-6-carboxanilides and -6- thiocarboxanilides represent a novel series of anthelmintic compounds, with broad-spectrum activity against important parasitic nematodes in sheep and dogs. In particular, an improved efficacy against Trichostrongylus colubriformis in sheep over the related 3-carbamoyl-4-hydroxycoumarins has been noted. New synthetic routes to the key intermediate, 7- hydroxythieno[3,2-b]pyran-5-one, have been developed.