186758-21-4

Basic information

• Product Name: methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate
• Synonyms: methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate
• CAS NO: 186758-21-4
• Molecular Weight: 198.169
• Mol File: 186758-21-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate(186758-21-4)
• EPA Substance Registry System: methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate(186758-21-4)

Safety Data

• Hazardous Substances Data: 186758-21-4(Hazardous Substances Data)

Upstream product

• 5927-18-4 trimethyl phosphonoacetate 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 94977-52-3 2,4-Difluorocinnamic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 923948-64-5 methyl (3S*,4R*)-1-benzyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate 
• 174729-90-9 methyl (2S,3R)-3-(2,4-difluorophenyl)-2,3-dihydroxypropionate 
• 455957-72-9 methyl (3R,4S)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate 
• 455957-73-0 methyl (3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)-pyrrolidine-3-carboxylate 

Relevant articles and documents

6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL

The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

NRF2 REGULATORS

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.

ETHER DERIVATIVES HAVING 5-LIPOXYGENASE INHIBITORY ACTIVITY

The invention concerns ether derivatives of the formula I Q1?X?Ar?Q2 wherein Q1 is an optionally substituted 9-, 10- or 11-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; X is oxy, thio, sulphinyl or sulphonyl; Ar is optionally substituted phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl, thiazolediyl, oxazoiediyl, thiadiazoiediyl or oxadiazolediyl; and Q2 is selected from the groups of the formulae II and III: wherein R1 is hydrogen, (2-5C)alkanoyl or optionally substituted benzoyl; R2 is (l-4C)alkyl; and R3 is hydrogen or (l-4C)alkyl; or R2 and R3 are linked to form a methylene, vinylene, ethylene or trimethylene group; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.