187091-65-2

Basic information

• Product Name: Methanesulfonic acid (2R,3S)-1-benzyl-2-methyl-pyrrolidin-3-yl ester
• Synonyms: Methanesulfonic acid (2R,3S)-1-benzyl-2-methyl-pyrrolidin-3-yl ester
• CAS NO: 187091-65-2
• Molecular Weight: 269.365
• Mol File: 187091-65-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid (2R,3S)-1-benzyl-2-methyl-pyrrolidin-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid (2R,3S)-1-benzyl-2-methyl-pyrrolidin-3-yl ester(187091-65-2)
• EPA Substance Registry System: Methanesulfonic acid (2R,3S)-1-benzyl-2-methyl-pyrrolidin-3-yl ester(187091-65-2)

Safety Data

• Hazardous Substances Data: 187091-65-2(Hazardous Substances Data)

Upstream product

• 187091-54-9 (S)-1-Benzyl-4-benzyloxy-5-hydroxy-5-methyl-pyrrolidin-2-one 
• 187091-61-8 (-)-(4S,5R)-1-benzyl-4-benzyloxy-5-methyl-2-pyrrolidinone 
• 170711-05-4 (S)-1-benzyl-3-(benzyloxy)pyrrolidine-2,5-dione 
• 187091-63-0 (+)-(4S,5R)-1-benzyl-4-hydroxy-5-methyl-2-pyrrolidinone 
• 101469-91-4 (3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione 
• 129823-21-8 (S)-4-acetoxy-1-benzyl-2,5-pyrrolidinedione 
• 124-63-0 methanesulfonyl chloride 
• 187091-64-1 (-)-(2R,3S)-1-benzyl-3-hydroxy-2-methylpyrrolidine 

Downstream Products

• 187091-67-4 (-)-(2R,3R)-1-benzyl-2-methylpyrrolidin-3-amine 
• 187091-66-3 (-)-(2R,3S)-3-azido-1-benzyl-2-methylpyrrolidine 

Relevant articles and documents

An easy access to protected (4S, 5R)-5-alkyl-4-hydroxy-2-pyrrolidinones and their use as versatile synthetic intermediates

A versatile approach to enantiopure (4S, 5R)-5-alkyl-4-hydroxy-2- pyrrolidinones is described. The key steps involve a regioselective Grignard reagent addition to (S)-malimides, and diastereoselective reductive dehydroxylation of the resulting hemi-azaketals. The flexibility of this methodology has been demonstrated by the synthesis of (2R, 3R)-3-amino-1- benzyl-2-methylpyrrolidine, the parent diamine of antipsychotic agent, emonapride, and the unnatural enantiomer of the β-hydroxy-γ-amino acid residue of hapalosin in lactam form.