187336-16-9

Basic information

• Product Name: 1-(4-methoxyphenyl)-1-(quinazolin-4-yl)ethanol
• Synonyms: 1-(4-methoxyphenyl)-1-(quinazolin-4-yl)ethanol
• CAS NO: 187336-16-9
• Molecular Weight: 280.326
• Mol File: 187336-16-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxyphenyl)-1-(quinazolin-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-1-(quinazolin-4-yl)ethanol(187336-16-9)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-1-(quinazolin-4-yl)ethanol(187336-16-9)

Safety Data

• Hazardous Substances Data: 187336-16-9(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 5190-68-1 4-chloroquinazoline 
• 917-64-6 methyl magnesium iodide 
• 55326-10-8 (4-methoxyphenyl)(quinazolin-4-yl)methanone 

Downstream Products

• 253-82-7 quinazoline 
• 16499-37-9 quinazoline-4-carbonamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Synthesis and structure-activity relationship study of 1-phenyl-1-(quinazolin-4-yl)ethanols as anticancer agents

A quinazoline derivative PVHD121 (1a) was shown to have strong antiproliferative activity against various tumor-derived cell lines, including A549 (lung), NCI-H460 (lung), HCT116 (colon), MCF7 (breast), PC3 (prostate), and HeLa (cervical) cells with IC50 values from 0.1 to 0.3 M. A structure-activity relationship (SAR) study at the 2- and 4-position of the quinazoline core lead to the discovery of more potent anticancer agents (14, 16, 17, 19, 24, and 31). The results of an in vitro tubulin polymerization assay and fluorescent-based colchicine site competition assay with purified tubulin indicated that 1a inhibits tubulin polymerization by binding to the colchicine site.