18740-39-1

Basic information

• Product Name: 2,4-Dichlorothieno[2,3-d]pyrimidine
• Synonyms: 2,4-Dichlorothieno[2,3-d]pyrimidine;2,4-Dichlorothieno[2,3-d]...;Thieno[2,3-d]pyrimidine, 2,4-dichloro-
• CAS NO: 18740-39-1
• Molecular Formula: C₆H₂Cl₂N₂S
• Molecular Weight: 205.06448
• Product Categories: Heterocycles series;Heterocycle-Pyrimidine series
• Mol File: 18740-39-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 274.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.662 g/cm³
• Refractive Index: 1.714
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.84±0.40(Predicted)
• CAS DataBase Reference: 2,4-Dichlorothieno[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichlorothieno[2,3-d]pyrimidine(18740-39-1)
• EPA Substance Registry System: 2,4-Dichlorothieno[2,3-d]pyrimidine(18740-39-1)

Safety Data

• Statements: 36
• Safety Statements: 26
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 18740-39-1(Hazardous Substances Data)

Usage

General Description

2,4-Dichlorothieno[2,3-d]pyrimidine is a chemical compound belonging to the thienopyrimidine family. It is an organic compound containing two chlorine atoms and a thieno ring fused with a pyrimidine ring. 2,4-Dichlorothieno[2,3-d]pyrimidine is used as a building block in the synthesis of various pharmaceuticals and agricultural chemicals. Its unique structure and properties make it a valuable intermediate for the production of biologically active compounds, including potential drug candidates. Additionally, it has potential applications in the development of new materials and as a molecular probe in chemical research. However, due to its chemical properties and potential toxicity, proper handling and safety precautions should be taken when working with 2,4-Dichlorothieno[2,3-d]pyrimidine.

InChI:InChI=1/C6H2Cl2N2S/c7-4-3-1-2-11-5(3)10-6(8)9-4/h1-2H

Upstream product

• 18740-38-0 1H-thieno[2,3-d]pyrimidine-2,4-dione 
• 4651-82-5 2-amino-3-cyanothiophene 
• 503-38-8 trichloromethyl chloroformate 
• 4651-81-4 Methyl 2-aminothiophene-3-carboxylate 
• 56844-43-0 2-chlorothieno-[2,3-d]-pyrimidin-4(3H)-one 

Downstream Products

• 134372-89-7 2-Chloro-4-(phenylamino)thieno[2,3-d]pyrimidine 
• 1607479-51-5 C₂₂H₂₄N₈OS 
• 1607479-52-6 C₂₁H₂₂N₈OS 
• 1542704-20-0 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzylthieno[2,3-d]pyrimidin-4-amine 
• 63894-64-4 benzyl-(2-chloro-thieno[2,3-d]pyrimidin-4-yl)-amine 
• 1620147-31-0 2-chloro-4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidine 
• 1620147-50-3 N-(2,6-dimethylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzamide 
• 1620147-47-8 N-(2-methyl-5-(morpholinylmethyl)phenyl)-4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzamide 
• 1620147-46-7 N-(2-methyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzamide 
• 1620147-43-4 N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzamide 
• 1620147-40-1 N-(5-(hydroxymethyl)-2-methylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzamide 
• 1620147-37-6 4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzoic acid 
• 1620147-34-3 methyl 4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzoate 
• 1436866-42-0 ethyl 2-[4-[(2-chlorothieno[2,3-d]pyrimidin-4-yl)amino]phenyl]acetate 

Relevant articles and documents

Synthesis, Anti-Microbial Activity, and Docking Studies of Novel N-Pyridine Substituted 2-Chlorothieno[2,3-d]pyrimidine Derivatives

Abstract: A series of novel N-pyridine substituted 2-chloro-thieno[2,3-d]pyrimidin-4-amine derivatives has beensynthesized and characterized by 1H and13C NMR spectrometry. All the compounds have beendocked against acetyl-CoA carboxylase enzyme and also tested for their in vitro antimicrobial activity on Gram-positive(Micrococcus luteus, staphylococcusaureus) and Gram-negative bacteria (Salmonella typhi, klebsiella pneumoniae), and anti-fungalactivity on aspergillus niger and fusarium oxysporum. All synthesized compounds havedemonstrated moderate activity, and two products have exhibited goodantibacterial and antifungal activity.

Pyrimidine derivatives, preparation method therefor and application of pyrimidine derivatives

The invention belongs to the field of drug synthesis and relates to novel pyrimidine derivatives, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, preparation methods of thenovel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof and use of the novel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof in preparation of therapeutic agents, particularly PAK inhibitors. The derivatives disclosed by the invention are represented by a general formula (I) or (II), wherein each substituent is as defined in claims.

Polyphenol compounds

PROBLEM TO BE SOLVED: To provide a polyphenol compound which has an inhibitory activity for poly(ADP-ribose)glycohydrase (PARG) and is useful as an anticancer agent or the like.SOLUTION: There is provided a polyphenol compound represented by the formula (I) or a pharmaceutically acceptable salt thereof (where, X represents a mono to tri-valent aromatic hydrocarbon group or aromatic heterocyclic group or the like; Y represents -N(R)-, -NHCO- or a bond; Rand Rrepresent a hydrogen atom, an alkyl group or the like; n represents 1, 2 or 3; and m represents an integer of 2 to 5.)