187848-68-6 Usage
Description
O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000, also known as t-Boc-Aminooxy-PEG12-acid, is a water-soluble polyethylene glycol (PEG) reagent with a molecular weight of 3,000. It features a terminal carboxylic acid that can react with primary amine groups in the presence of activators, such as EDC or HATU, to form a stable bond. The Boc-protected amine group in the molecule can be deprotected under mild acidic conditions, making it a versatile compound for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000 is used as a conjugation agent for the attachment of therapeutic molecules, such as drugs or peptides, to PEG. This PEGylation process enhances the solubility, stability, and circulation time of the therapeutic molecules in the body, leading to improved pharmacokinetics and reduced immunogenicity.
Used in Bioconjugation and Drug Delivery:
O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000 is used as a bioconjugation agent for the covalent attachment of biologically active molecules to PEG. This allows for the creation of stable conjugates with improved properties, such as increased solubility, reduced aggregation, and enhanced bioavailability. Additionally, it can be used in the development of drug delivery systems, where the PEGylated molecules can be targeted to specific cells or tissues, improving the efficacy and reducing the side effects of the therapeutic agents.
Used in Diagnostics and Imaging:
O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000 can be used as a component in the development of diagnostic and imaging agents. By attaching contrast agents or imaging labels to PEG, the resulting conjugates can be used to enhance the visibility of specific biological structures or processes, allowing for improved diagnostic capabilities.
Used in Material Science:
O-[2-(Boc-amino)ethyl]-Oμ-(2-carboxyethyl)polyethylene glycol 3,000 can be utilized in the development of novel materials with tailored properties. The PEG reagent can be incorporated into polymers, hydrogels, or other materials to improve their biocompatibility, water solubility, and mechanical properties, making them suitable for various applications, such as tissue engineering, drug delivery, and sensors.
Check Digit Verification of cas no
The CAS Registry Mumber 187848-68-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,8,4 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 187848-68:
(8*1)+(7*8)+(6*7)+(5*8)+(4*4)+(3*8)+(2*6)+(1*8)=206
206 % 10 = 6
So 187848-68-6 is a valid CAS Registry Number.
