188054-45-7 Usage
Description
4-acridinecarboxylic acid methyl ester, also known as acridine-4-carboxylic acid methyl ester, is a versatile chemical compound belonging to the acridine family. It is a derivative of acridine with a methyl ester group attached to the carboxylic acid moiety, exhibiting potential biological activities and serving as a building block in organic synthesis and medicinal chemistry.
Uses
Used in Organic Synthesis and Medicinal Chemistry:
4-acridinecarboxylic acid methyl ester is used as a building block for the preparation of various acridine-based compounds with potential biological activities, such as antitumor, antimicrobial, and antiviral properties.
Used in Antitumor Applications:
4-acridinecarboxylic acid methyl ester is used as an antitumor agent, exhibiting potential in the development of acridine-based compounds with therapeutic effects against cancer.
Used in Antimicrobial Applications:
4-acridinecarboxylic acid methyl ester is used as an antimicrobial agent, showing potential in the development of acridine-based compounds with activity against various microorganisms.
Used in Antiviral Applications:
4-acridinecarboxylic acid methyl ester is used as an antiviral agent, demonstrating potential in the development of acridine-based compounds with activity against various viruses.
Used in Fluorescent Probes for DNA and RNA Visualization:
4-acridinecarboxylic acid methyl ester is used as a fluorescent probe for the visualization of DNA and RNA, enabling the study of nucleic acid structures and interactions.
Used in Photodynamic Therapy:
4-acridinecarboxylic acid methyl ester is used as a photosensitizer in photodynamic therapy, where it can generate reactive oxygen species upon light activation, leading to the destruction of target cells.
Check Digit Verification of cas no
The CAS Registry Mumber 188054-45-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,0,5 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 188054-45:
(8*1)+(7*8)+(6*8)+(5*0)+(4*5)+(3*4)+(2*4)+(1*5)=157
157 % 10 = 7
So 188054-45-7 is a valid CAS Registry Number.
188054-45-7Relevant articles and documents
Preparation method of multi-functional group acridine compound and derivative thereof
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Paragraph 0145; 0146; 0148; 0149; 0162; 0163; 0164; 0165, (2017/02/17)
The present invention relates to a preparation method of a multi-functional group acridine compound and a derivative thereof. According to the present invention, specifically a bisphosphine ligand and palladium complex catalyzed series connection coupling/cyclization reaction is used to prepare the acridine compound represented by a formula I, wherein various groups are defined in the specification; and the method has advantages of mild reaction condition, simple operation and wide substrate applicability, and the multi-functional group acridine compound and the derivative thereof can be prepared in the high yield manner. The formula I is defined in the specification.
Process for the preparation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
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, (2008/06/13)
PCT No. PCT/GB97/02884 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17649 PCT Pub. Date Apr. 30, 1998A process for producing an acridine carboxamide of formula (I): wherein each of R1, R2, R5 and R6,
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl] acridine- 4-carboxamide
Spicer, Julie A.,Gamage, Swarna A.,Atwell, Graham J.,Finlay, Graeme J.,Baguley, Bruce C.,Denny, William A.
, p. 1919 - 1929 (2007/10/03)
The mixed topoisomerase I/II inhibitor N-[2- (dimethylamino)ethyl]acridine-4-carboxamide (DACA) is currently in clinical trial as an anticancer drug. A series of acridine-substituted analogues were prepared, using a new synthetic route to substituted acri
