1885-81-0

Basic information

• Product Name: 1-CHLORO-4-ISOCYANOBENZENE
• Synonyms: BIO-FARMA BF001949;HANSA ISN-0726;4-CHLOROPHENYL ISOCYANIDE;4-CHLORPHENYLISOCYANIDE;1-CHLORO-4-ISOCYANOBENZENE;Benzene, 1-chloro-4-isocyano- (9CI);Chlorophenylisocyanate (3,4 -isomer);p-Chlorophenyl isocyanide
• CAS NO: 1885-81-0
• Molecular Formula: C₇H₄ClN
• Molecular Weight: 137.57
• Product Categories: ISONITRITE
• Mol File: 1885-81-0.mol
• Article Data: 30

Chemical Properties

• Melting Point: 71-75 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 1-CHLORO-4-ISOCYANOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-4-ISOCYANOBENZENE(1885-81-0)
• EPA Substance Registry System: 1-CHLORO-4-ISOCYANOBENZENE(1885-81-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1885-81-0(Hazardous Substances Data)

Usage

General Description

1-CHLORO-4-ISOCYANOBENZENE is a compound with the chemical formula C7H4ClNO. It belongs to the class of aromatic isocyanides, which are molecules containing an isocyanide group (-N≡C) attached to an aromatic ring. This chemical is used as an intermediate in the production of pharmaceuticals, dyes, and other organic compounds. It is a highly reactive compound that is sensitive to moisture and air, and should be handled with care. 1-CHLORO-4-ISOCYANOBENZENE has the potential to cause skin and eye irritation, and can also be harmful if inhaled or ingested. Therefore, proper safety precautions should be taken when handling this chemical.

InChI:InChI=1/C7H4ClN/c1-9-7-4-2-6(8)3-5-7/h2-5H

Upstream product

• 2617-79-0 N-(4-chlorophenyl)formamide 
• 106-47-8 4-chloro-aniline 
• 3696-23-9 N-(4-chlorophenyl)thiourea 
• 104-12-1 p-chlorphenylisocyanate 
• 2771-67-7 N-dichloromethylene-4-chloroaniline 
• 34070-24-1 Dichlormethansulfonsaeure-<4-chlor-anilid> 
• 67-66-3 chloroform 

Downstream Products

• 13463-94-0 N-(4-chlorophenyl)cyanamide 
• 935756-06-2 5-chloro-1-[3,3-dimethyl-2-oxo-1-(p-tolyl)azetidin-4-yl]-2-[(Z)-3,3-dimethyl-2-oxo-1-(p-tolyl)azetidin-4-ylidene]-3-(p-chlorophenylimino)-2,3-dihydroindole 
• 935756-10-8 5-chloro-1-[3,3-dimethyl-2-oxo-1-(p-chlorophenyl)azetidin-4-yl]-2-[(Z)-3,3-dimethyl-2-oxo-1-(p-chlorophenyl)azetidin-4-ylidene]-3-(p-chlorophenylimino)-2,3-dihydroindole 
• 107599-25-7 RhCl{P(OCH(CH₃)2)3}2(ClC₆H₄NC) 
• 210823-65-7 [ReBr₂(NNC₆H₅)(CNC₆H₄Cl)(P(C₆H₅)3)2] 
• 1141508-40-8 1-(4-chlorophenyl)-3-(fluorocarbonyl)-2-oxo-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide 
• 1160652-89-0 [Rh(2,2'-bipyridine)(CNC₆H₄Cl-4)2]BF₄ 
• 1191080-70-2 trans,trans,trans-[Ru(8-quinolinolato)2(4-chlorophenyl isocyanide)2] 
• 1376615-60-9 C₂₁H₁₆ClFN₂O₄ 

Relevant articles and documents

Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Bromodomain-containing Protein 4 (BRD4), an ‘epigenetic reader’, regulates chromatin structure and gene expression via recognizing and binding acetylated lysine in histones. BRD4 has become a therapeutic target for cancers because it promotes the expression of the tumor genes, such as c-Myc, NF-κB, and Bcl-2. In this study, a new series of 3-methyl-1H-indazole derivatives were designed via virtual screening and structure-based optimization. All compounds were synthesized and evaluated for their inhibitory activities to BRD4-BD1 and their antiproliferative effects in cancer cell lines. Among them, several compounds (such as 9d, 9u and 9w) exhibited strong BRD4-BD1 affinities and inhibition activities, and potently suppressed MV4;11 cancer cell line proliferation. Among them, compound 9d showed excellent selectivity for BRD4 and effectively suppressed c-Myc, the downstream protein of BRD4. This study provided new lead compounds for further biological evaluation on BRD4.

Visible-light-induced radical cascade cyclization of oxime esters and aryl isonitriles: Synthesis of cyclopenta[: B] quinoxalines

A visible-light-induced radical cascade cyclization of aryl isonitriles and cyclobutanone oxime esters for the synthesis of cyclopenta[b]quinoxalines has been accomplished for the first time. The key to the success of this process was the integration of the in situ-formed nitrile radical followed by the cascade radical isonitrile/nitrile insertion-cyclization. The easy introduction of substituents for both substrates and the high functional group tolerance of the reaction make it an efficient strategy to give various quinoxaline derivatives in moderate to good yields.

Dramatically Enhanced Solubility of Halide-Containing Organometallic Species in Diiodomethane: The Role of Solvent???Complex Halogen Bonding

In the current study, we evaluated the solubility of a number of organometallic species and showed that it is noticeably improved in diiodomethane when compared to other haloalkane solvents. The better solvation properties of CH2I2 w