188524-64-3Relevant articles and documents
Non-redox metal ion promoted oxidative coupling of indoles with olefins by the palladium(II) acetate catalyst through dioxygen activation: Experimental results with DFT calculations
Zhang, Sicheng,Chen, Zhuqi,Qin, Shuhao,Lou, Chenlin,Senan, Ahmed M.,Liao, Rong-Zhen,Yin, Guochuan
, p. 4146 - 4157 (2016)
Developing new catalytic technologies through C-H bond activation to synthesize versatile pharmaceuticals has attracted much attention in recent decades. This work introduces a new strategy in catalyst design for Pd(ii)-catalyzed C-H bond activation in wh
Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors
Kim, Minkyoung,Kwon, Jinsun,Kim, Mun Ock,Singh, Sarbjit,Kim, Sang Kyum,Lee, Kyeong,Lee, Kiho,Lee, Hyun Sun,Choi, Yongseok
, p. 628 - 635 (2015/05/04)
A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.
REGIOSELECTIVE VINYLATION OF INDOLES WITH OLEFINS AND PdCl2
Murakami, Yasuoki,Yokoyama, Yuusaku,Aoki, Tsuyoshi
, p. 522 (2007/10/02)
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