188699-82-3Relevant articles and documents
Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist
Tvaermose-Nielsen, Ole,Rachlin, Schneur,Dannacher, Heinz,Bjoerkling, Fredrik,Kirstein, Dorte,Bramm, Erik,Kaergaard Nielsen, Christian,Mortensen, Jens Thing,Binderup, Lise
, p. 415 - 427 (2007/10/03)
The present paper describes the structural modifications leading to the discovery of a new series of quinoline-containing cys-LT1 receptor (LTD4 receptor) antagonists. A structural optimization with respect to the in vitro receptor b