188845-76-3

Basic information

• Product Name: (7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^3,7]decane-4-hydroxamic acid
• Synonyms: (7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^3,7]decane-4-hydroxamic acid
• CAS NO: 188845-76-3
• Molecular Weight: 274.341
• Mol File: 188845-76-3.mol
• Article Data: 2

Chemical Properties

• Density: 1.48±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^3,7]decane-4-hydroxamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^3,7]decane-4-hydroxamic acid(188845-76-3)
• EPA Substance Registry System: (7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^3,7]decane-4-hydroxamic acid(188845-76-3)

Safety Data

• Hazardous Substances Data: 188845-76-3(Hazardous Substances Data)

Upstream product

• 108448-77-7 (+)-camphorsultam 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 108448-77-7 (+)-camphorsultam 
• 287117-69-5 (1R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carboxylic acid-(2-oxo-cyclohex-3-enyl)-amide 
• 287117-72-0 (1S,2R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carboxylic acid-(2-hydroxy-cyclohex-3-enyl)-amide 

Relevant articles and documents

A formal asymmetric synthesis of (-)-epibatidine using a highly diastereoselective hetero Diels-Alder reaction

A formal asymmetric synthesis of (-)-epibatidine is reported. The key step of the synthesis is a regio- and diastereoselective cycloaddition of silyloxycyclohexadiene with the acylnitroso dienophite derived from (+)- camphorsultam. The resulting cycloadduct was readily transformed into the N- protected-7-azabicycto[2.2.1]heptan-2-one derivative which has previously been transformed into(-)-epibatidine. (C) 2000 Elsevier Science.