189120-01-2

Basic information

• Product Name: 2-(4-BROMOPHENYL)-4,5-DIHYDROOXAZOLE
• Synonyms: 2-(4-BROMOPHENYL)-4,5-DIHYDROOXAZOLE
• CAS NO: 189120-01-2
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.07
• Mol File: 189120-01-2.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-BROMOPHENYL)-4,5-DIHYDROOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOPHENYL)-4,5-DIHYDROOXAZOLE(189120-01-2)
• EPA Substance Registry System: 2-(4-BROMOPHENYL)-4,5-DIHYDROOXAZOLE(189120-01-2)

Safety Data

• Hazardous Substances Data: 189120-01-2(Hazardous Substances Data)

Usage

Molecular Weight

214.06 g/mol

Class

Heterocyclic compound

Structure

Five-membered aromatic ring containing one oxygen and one nitrogen atom, with a 4-bromophenyl group attached to the second carbon atom.

Bromine Content

The presence of a bromine atom in the phenyl group.

Potential Applications

Pharmaceutical, agrochemical, and materials science industries.

Safety Precautions

Handle with caution and follow proper safety protocols in a laboratory setting.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 586-76-5 4-Bromobenzoic acid 
• 26197-93-3 p-bromothiobanzamide 
• 141-43-5 ethanolamine 
• 586-75-4 4-chlorobenzoyl chloride 
• 623-00-7 4-bromobenzenecarbonitrile 
• 57728-67-3 N-(2-hydroxyethyl)-p-bromobenzamide 
• 1122-91-4 4-bromo-benzaldehyde 
• 873-75-6 4-bromobenzenemethanol 
• 18292-63-2 1-(p-bromobenzoyl)aziridine 
• 5798-75-4 Ethyl 4-bromobenzoate 

Downstream Products

• 914076-87-2 C₁₈H₁₅NO 
• 1142955-23-4 C₂₀H₁₆N₂O₂ 
• 1142955-21-2 C₁₄H₁₇NOSi 
• 176961-50-5 2-(4-bromophenyl)oxazole 
• 1259319-70-4 cyanomethyl 4-bromobenzoate 

Relevant articles and documents

Facile one-pot synthesis of 2-oxazoline

We developed a facile one-pot synthesis of 2-oxazolines from carboxylic acid and 2-chloroethyl isocyanate, involving amide bond formation and a following intramolecular cyclization using 4-dimethylaminopyridine as the catalyst. A large variety of functional groups are well tolerated by the mild reaction conditions to afford diverse 2-oxazolines in good to excellent yields. This reaction will keep the chirality of the isocyanate at position 1, the R2 substituted carbon. Microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time to 5 min. This method facilities the synthesis of 2-oxazolines for diverse applications, such as 2-oxazoline derived polymers and materials.

Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones

The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.

Oxazolinyl-Assisted Ru(II)-Catalyzed C?H Functionalization Based on Carbene Migratory Insertion: A One-Pot Three-Component Cascade Cyclization

A rare, ruthenium-catalyzed, oxazolinlyl assisted C?H functionalization and three-component cascade cyclization for the synthesis of isoquinolinones via a metal-carbene migratory insertion is reported. The transformation is unique since it involves the fo