189188-57-6 Usage
Description
Tegaserod maleate was launched as a new oral treatment of constipationpredominant
or diarrhea-predominant irritable bowel syndrome. It can be prepared by
condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine.
Tegaserod is a selective partial agonist of the excitatory 5-HT4 receptor (K1 = 18 nM in
human caudate membranes) and was designed from the endogenous full agonist,
seretonin. In the model of potentiation of the electrically stimulated contraction of
longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic
activity compared with serotonin. However, it appeared more potent in several studies on
intestinal mucosal tissue from various species including man. A lack of effect on the QTc
interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also
clinically developed for the treatment of other functional GI disorders such as functional
dyspepsia and gastroesophageal reflux disease (GERD).
Chemical Properties
White Powder
Originator
Novartis (Switzerland)
Uses
Different sources of media describe the Uses of 189188-57-6 differently. You can refer to the following data:
1. Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.
2. Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.
Brand name
Zelnorm
(Novartis);Zelmac.
Biochem/physiol Actions
It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.
Check Digit Verification of cas no
The CAS Registry Mumber 189188-57-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,1,8 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 189188-57:
(8*1)+(7*8)+(6*9)+(5*1)+(4*8)+(3*8)+(2*5)+(1*7)=196
196 % 10 = 6
So 189188-57-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1-
189188-57-6Relevant articles and documents
New tegaserod maleate polymorphs and process for their preparation
-
Page/Page column 4, (2008/12/07)
The present invention refers to two new tegaserod maleate polymorfs (α and β) and to processes for their preparation.
NOVEL CRYSTALLINE FORMS OF TEGASEROD MALEATE
-
Page 4, (2008/06/13)
The present invention relates to novel crystalline forms to tegaserod maleate, to processes for their preparation and to pharmaceutical compositions containing them.
