189341-61-5Relevant articles and documents
Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases
Thomson, Andrew,O'Connor, Sean,Knuckley, Bryan,Causey, Corey P.
, p. 4602 - 4608 (2014)
Agmatine deiminases (AgDs) belong to a family of enzymes known as guanidinium group modifying enzymes (GMEs). Many pathogenic bacteria encode an AgD that participates in the catabolism of agmatine (decarboxylated arginine). This catabolism may confer a co
General Approach for the Liquid-Phase Fragment Synthesis of Orthogonally Protected Naturally Occurring Polyamines and Applications Thereof
Kalantzi, Stefania,Athanassopoulos, Constantinos M.,Ruonala, Raili,Helariutta, Yrjo,Papaioannou, Dionissios
, p. 15118 - 15130 (2019/11/19)
Orthogonally protected polyamines (PAs) have been synthesized using α,ω-diamines and ω-aminoalcohols as N-Cx-N and N-Cy synthons, respectively, and the Mitsunobu reaction as the key reaction for the assembly of the PA skeleta. The Trt, Dde, and Phth groups have been employed for protecting the primary amino functions and the Ns group for activating the primary amino functions toward alkylation and secondary amino function protection. The approach has been readily extended to accommodate the total synthesis of the spider toxins Agel 416 and HO-416b, incorporating the 3-4-3-3 and the 3-3-3-4 PA skeleton, respectively.
Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines
Magoulas, George E.,Bariamis, Stavros E.,Athanassopoulos, Constantinos M.,Papaioannou, Dionissios
supporting information; experimental part, p. 1989 - 1993 (2010/06/21)
Syntheses of novel polyamine-modified minoxidil analogs (PMMs) and minoxidil-polyamine conjugates (MPCs) are described in an effort to improve the biological activity and selectivity of minoxidil and its poor solubility in water.
