189348-38-7

Basic information

• Product Name: 2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione
• CAS NO: 189348-38-7
• Molecular Weight: 320.391
• Mol File: 189348-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione(189348-38-7)
• EPA Substance Registry System: 2,5-dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3-dione(189348-38-7)

Safety Data

• Hazardous Substances Data: 189348-38-7(Hazardous Substances Data)

Usage

Molecular weight

293.35 g/mol

Structure

DPTP has a complex molecular structure that consists of a pyrrolidine ring fused with a pyrrole ring, and two benzene rings attached to the nitrogen atom of the pyrrolidine ring.

Appearance

Yellow crystalline solid

Solubility

Insoluble in water, slightly soluble in methanol, and soluble in chloroform and acetonitrile.

Biological activity

DPTP has been studied for its potential as a therapeutic agent, particularly for its neuroprotective and anti-inflammatory properties.

Use in research

DPTP is commonly used in organic synthesis and pharmaceutical research due to its potential biological activity.

Drug development

Its unique structure and properties make it a valuable target for drug development, and it continues to be the subject of ongoing research in the field of medicinal chemistry.

Upstream product

• 1631-26-1 1-benzyl-1H-pyrrole-2,5-dione 
• 17136-36-6 N-benzylglycine 

Downstream Products

• 172739-04-7 cis-3-benzyl-3,7-diazabicyclo[3.3.0]octane 
• 872001-73-5 (5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethylpyrimidin-5-yl)methanone 
• 1220514-61-3 (4,6-dimethylpyrimidin-5-yl)(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone benzylmalonic acid salt 
• 872001-56-4 [(S)-3-[5-(4,6-Dimethylpyrimidine-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-(3-fluorophenyl)propyl]carbamic acid tert-butyl ester 
• 872001-57-5 {5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone 
• 1220514-59-9 {5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone tartaric acid salt 
• 1220514-67-9 C₂₇H₃₄FN₅O₃ 
• 1220514-58-8 C₂₇H₃₄FN₅O₃*ClH 

Relevant articles and documents

Practical asymmetric synthesis of RO5114436, a CCR5 receptor antagonist

A practical asymmetric synthesis of a 3,7-diazabicyclo[3.3.0]octane derivative (1), a representative of a new class of potent CCR5 receptor antagonists, is described. The benzylamine stereogenic center of 1 was introduced by a ruthenium-catalyzed asymmetric reductive amination using (R)-MeOBIPHEP as ligand. Aldehyde 4, prepared by Parikh-Doering oxidation, was used without workup in the reductive amination reaction, which not only simplified the process but also overcame the instability of 4. The 3,7-diazabicyclo[3.3.0]octane core was obtained by a [3 + 2] cycloaddition.