189442-87-3 Usage
Description
Ethyl N-Boc-4-methylpiperidine-4-carboxylate is a chemical compound that serves as an essential intermediate in the synthesis of various pharmaceuticals and bioactive molecules. It is characterized by its unique molecular structure, which includes a Boc-protected 4-methylpiperidine core and a carboxylate group attached to an ethyl ester. Ethyl N-Boc-4-methylpiperidine-4-carboxylate is valuable in the development of new drugs and therapeutic agents due to its versatile reactivity and potential for functionalization.
Uses
Used in Pharmaceutical Industry:
Ethyl N-Boc-4-methylpiperidine-4-carboxylate is used as a reactant for the synthesis of Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as ABT-279. These inhibitors play a crucial role in the treatment of type 2 diabetes by regulating glucose levels in the body. The compound's unique structure allows for the development of potent and selective DPP-4 inhibitors, which can help improve the management of diabetes and its associated complications.
Used in Medicinal Chemistry:
Ethyl N-Boc-4-methylpiperidine-4-carboxylate is used as a building block for the synthesis of piperazine-based CCR5 antagonists. These antagonists are important in the field of medicinal chemistry, as they have the potential to modulate the immune system and exhibit anti-inflammatory, anti-allergic, and anti-cancer properties. The compound's structural diversity and reactivity make it an ideal candidate for the development of novel piperazine-based CCR5 antagonists with improved pharmacological profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 189442-87-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,4,4 and 2 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 189442-87:
(8*1)+(7*8)+(6*9)+(5*4)+(4*4)+(3*2)+(2*8)+(1*7)=183
183 % 10 = 3
So 189442-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H25NO4/c1-6-18-11(16)14(5)7-9-15(10-8-14)12(17)19-13(2,3)4/h6-10H2,1-5H3
189442-87-3Relevant articles and documents
Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore
Barraza, Scott J.,Sindac, Janice A.,Dobry, Craig J.,Delekta, Philip C.,Lee, Pil H.,Miller, David J.,Larsen, Scott D.
supporting information, (2021/06/18)
We have previously reported the development of indole-based CNS-active antivirals for the treatment of neurotropic alphavirus infection, but further optimization is impeded by a lack of knowledge of the molecular target and binding site. Herein we describe the design, synthesis and evaluation of a series of conformationally restricted analogues with the dual objectives of improving potency/selectivity and identifying the most bioactive conformation. Although this campaign was only modestly successful at improving potency, the sharply defined SAR of the rigid analogs enabled the definition of a three-dimensional pharmacophore, which we believe will be of value in further analog design and virtual screening for alternative antiviral leads.
CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF
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Paragraph 0185; 0186, (2019/04/05)
Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.
NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS
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Paragraph 61, (2018/10/19)
This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.
