189956-45-4Relevant articles and documents
Industrial synthesis method of rilpivirine and intermediate compound
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Paragraph 0028; 0041; 0042; 0068; 0077; 0086; 0095; 0104, (2017/10/07)
The invention discloses an industrial synthesis method of rilpivirine. A compound as shown in a formula I and compound hydrochloride as shown in a formula VI react to obtain rilpivirine. The invention further discloses an intermediate compound as shown in the formula I and a synthesis method of the intermediate compound. Compared with the prior art, the synthesis method is simple to operate, mild in condition, high in yield and purity and suitable for industrial production.
4-[ (4-chloro-2-pyrimidinyl) amino] phenyl nitrile preparation method
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Paragraph 0032-0034, (2020/05/01)
The invention discloses a new preparation method of 4-[(4-chlorine-2-pyrimidyl)amino] cyanophenyl. The preparation method comprises the steps of carrying out a reaction on N-guanidine cyanophenyl and NN,-dimethyl amino acrylate to generate II, and then carrying out chlorination on equivalent phosphorus oxychloride to generate a target product. By adopting the preparation method, the yield and the quality of the product can be improved; the cost is reduced, and the method is simple and convenient to operate, and suitable for a synthetic route of rilpivirine bodbody in industrial production.
PROCESS FOR RILPIVIRINE
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Paragraph 0081, (2014/08/19)
The present invention provides a novel process for the preparation of 4-(4-hydroxypyrimidin-2-ylamino)benzonitrile. The present invention also provides a novel process for the preparation of 4-iodo-2,6-dimethyl benzenamine. The present invention further provides an improved process for the preparation of rilpivirine. The present invention further provides a tosylate salt of rilpivirine, process for its preparation and pharmaceutical compositions comprising it.