190271-89-7

Basic information

• Product Name: 1,2,4-Butanetricarboxylic acid, 1-phenyl-
• CAS NO: 190271-89-7
• Molecular Formula: C13H14O6
• Molecular Weight: 266.251
• Mol File: 190271-89-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,2,4-Butanetricarboxylic acid, 1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Butanetricarboxylic acid, 1-phenyl-(190271-89-7)
• EPA Substance Registry System: 1,2,4-Butanetricarboxylic acid, 1-phenyl-(190271-89-7)

Safety Data

• Hazardous Substances Data: 190271-89-7(Hazardous Substances Data)

Usage

Synonyms

1-phenyl-1,2,4-butanetricarboxylic acid

Physical state

White crystalline solid

Functional groups

Carboxylic acid with three carboxyl groups on a four-carbon chain and a phenyl group attached to one of the carbon atoms

Uses

a. Crosslinking agent in the production of resins and polymers
b. Chemical intermediate in the synthesis of various organic compounds

Safety concerns

Potential harmful effects on human health and the environment

Handling and disposal

Should be handled and disposed of with care, following proper safety guidelines and regulations

Upstream product

• 100-52-7 benzaldehyde 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 5473-13-2 ethyl 2,3-dicyano-3-phenylpropanoate 
• 623-71-2 ethyl 3-chloropropanoate 
• 873380-10-0 2-cyano-2-(cyano-phenyl-methyl)-glutaric acid diethyl ester 

Downstream Products

• 3033-55-4 trans-(+/-)-2-Phenylcyclopentan-3-one-1-carboxylic acid 
• 909784-70-9 [(1S,2R,3R)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-cyclopentyl]-carbamic acid (S)-1-phenyl-ethyl ester 
• 909784-71-0 [(1R,2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-cyclopentyl]-carbamic acid (S)-1-phenyl-ethyl ester 

Relevant articles and documents

Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

An initial investigation of the novel cyclopentane scaffold 6 afforded low nanomolar human NK1 antagonists having enhanced water solubility properties compared to morpholine 1. A synthesis of this cyclopentane scaffold, having three contiguous chiral cent

Phenyl spiroethercycloalkyl tachykinin receptor antagonists

The present invention is directed to certain novel compounds represented by structural formula I: STR1 or a pharmaceutically acceptable salt thereof, wherein R 3, R 6, R 7, R 8, R 11, R 12, R 13, m, n and the dashed lines are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.

CYCLOALKYL TACHYKININ RECEPTOR ANTAGONISTS

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