190273-74-6 Usage
Chemical compound
2-Amino-5-(trifluoromethyl)quinazoline
Classification
Quinazoline
Appearance
White solid
Pharmaceutical interest
Potential anti-cancer agent
Mechanism of action
Inhibition of enzymes involved in cancer cell proliferation
Applications
Synthesis of organic compounds, reagent in chemical reactions
Scientific interest
Subject of investigation in medicinal chemistry and organic synthesis
Check Digit Verification of cas no
The CAS Registry Mumber 190273-74-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,2,7 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 190273-74:
(8*1)+(7*9)+(6*0)+(5*2)+(4*7)+(3*3)+(2*7)+(1*4)=136
136 % 10 = 6
So 190273-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3N3/c10-9(11,12)6-2-1-3-7-5(6)4-14-8(13)15-7/h1-4H,(H2,13,14,15)
190273-74-6Relevant articles and documents
Synthesis of 2-Aminoquinazolines from ortho-Fluorobenzaldehydes
Hynes, John B.,Campbell, Johnny P.
, p. 385 - 387 (2007/10/03)
The reaction of guanidine carbonate with various ortho-fluorobenzaldehydes in N,N-dimethylacetamide was investigated as a potential route for preparing 2-aminoquinazolines. Eleven new 2-aminoquinazolines were elaborated in this manner in low to moderate yields. In general the best results were obtained with ortho-fluorobenzaldehydes possessing an electron withdrawing substituent at the other ortho position. Complex mixtures were obtained using 2-fluorobenzaldehyde, 2,5-difluorobenzaldehyde and 2-fluoro-5-methoxybenzaldehyde which were not resolved.
