190278-37-6

Basic information

• Product Name: 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one
• Synonyms: 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one
• CAS NO: 190278-37-6
• Molecular Weight: 481.505
• Mol File: 190278-37-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one(190278-37-6)
• EPA Substance Registry System: 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one(190278-37-6)

Safety Data

• Hazardous Substances Data: 190278-37-6(Hazardous Substances Data)

Upstream product

• 28448-04-6 3-nitrocoumarin 
• 58-74-2 Papaverine 
• 90-02-8 salicylaldehyde 
• 38464-20-9 4-chloro-3-nitro-chromen-2-one 
• 119-36-8 methyl salicylate 

Relevant articles and documents

Visible-Light-Promoted and Yb(OTf)3-Catalyzed Constructions of Coumarin-Pyrrole-(Iso)quinoline-Fused Pentacycles: Synthesis of Lamellarin Core, Lamellarin D Trimethyl Ether, and Lamellarin H

The efficient construction of a coumarin-pyrrole-isoquinoline-fused pentacycle via the visible-light-promoted cyclization of 4-(isoquinolin-1-ylmethyl)-3-nitrocoumarin or Yb(OTf)3-catalyzed coupling of 4-chloro-3-nitrocoumarin and 1-methylisoqu

Construction of Pentacyclic Lamellarin Skeleton via Grob Reaction: Application to Total Synthesis of Lamellarins H and D

An efficient construction of phenyl-substituted coumarin-pyrrole-isoquinoline-fused pentacycle via base-promoted Grob-type coupling of 3-nitrocoumarin and papaverine in a sealed tube is reported. This reaction is further applied to the total synthesis of lamellarin H in three linear steps and lamellarin D in eight linear steps with overall yields of 31% and 14%, respectively.

Total syntheses of lamellarin D and H. The first synthesis of lamellarin-class marine alkaloids

Total syntheses of marine polyaromatic alkaloids, lamellarin D (1) and H (2), are described. The pentacyclic lamellarin ring system was constructed by N-ylide mediated pyrrole ring formation and subsequent lactonization of 4 obtained by an assembly of known benzylisoquinoline 5, benzoate 6 and ethyl bromoacetate.